AASDH
AASDH (aminoadipate-semialdehyde dehydrogenase) is an ATP-dependent enzyme that activates beta-alanine through a thioester bond with its phosphopantetheine group. It is also known as beta-alanine-activating enzyme, NRPS998, LYS2 and ACSF4. Browse Assay Genie's current range of AASDH research reagents below, or read on for the biology behind the target.
AASDH covalently binds beta-alanine in an ATP-dependent manner, forming a thioester bond with its phosphopantetheine group. It then transfers the activated beta-alanine to an acceptor that has not yet been identified. UniProt notes that the enzyme may be required for a post-translational protein modification or for the post-transcriptional modification of an RNA, so its biological role is still open.
The AASDH gene encodes a member of the non-ribosomal peptide synthetase (NRPS) enzyme family. The protein contains an AMP-binding domain, a phosphopantetheine (pantetheine 4'-phosphate) binding domain and a pyrroloquinoline quinone (PQQ) binding domain. It belongs to the ATP-dependent AMP-binding enzyme family and is classed by HGNC in the acyl-CoA synthetase family. According to the NCBI Gene summary, the protein is expressed in several adult tissues. UniProt does not currently annotate a subcellular location. A mouse ortholog, Aasdh, is recorded.
The gene has gone by several names, including NRPS998, LYS2 and ACSF4, and the HGNC name, aminoadipate-semialdehyde dehydrogenase, differs from the UniProt protein name, beta-alanine-activating enzyme. Researchers should be aware of these synonyms when searching the literature for AASDH. The related phosphopantetheinyl transferase AASDHPPT is a separate gene and is listed as a related target.
AASDH is a member of the NRPS enzyme family, making it a candidate for studying how this enzyme class functions in animal cells.
The enzyme activates beta-alanine in an ATP-dependent manner via a phosphopantetheine thioester, which makes it relevant to studies of beta-alanine handling.
UniProt suggests AASDH may be needed for a post-translational protein modification or an RNA modification, an open question for investigation.
As a member of the ATP-dependent AMP-binding enzyme family, AASDH supports comparative work across acyl-CoA synthetase-related enzymes.
AASDH binds beta-alanine covalently in an ATP-dependent reaction, forming a thioester with its phosphopantetheine group, and transfers it to an acceptor that is still unknown. It may be needed for a post-translational protein modification or an RNA modification.
AASDH is the HGNC symbol for aminoadipate-semialdehyde dehydrogenase. Aliases and previous symbols are NRPS998, LYS2 and ACSF4, and UniProt names the protein beta-alanine-activating enzyme. Check all of these names when searching the literature.
A mouse ortholog, Aasdh, is recorded for the human gene. The human protein belongs to the ATP-dependent AMP-binding enzyme family and contains AMP-binding, phosphopantetheine-binding and PQQ-binding domains. Check the datasheet of any product for its validated reactivity.
Pathway partners and enzymes linked to AASDH, including its phosphopantetheine-related relative, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q4L235; product specifications from Assay Genie datasheets.