NCOA3
NCOA3 (nuclear receptor coactivator 3) is a member of the SRC/p160 coactivator family that binds nuclear receptors and enhances their hormone-dependent transcriptional activity. It is also known as SRC-3, AIB1, RAC3, ACTR, p/CIP, TRAM-1 and KAT13B. Browse Assay Genie's current range of NCOA3 research reagents below, or read on for the biology behind the target.
NCOA3 is a nuclear receptor coactivator that binds nuclear receptors directly and stimulates their transcriptional activity in a hormone-dependent manner. It plays a central role in assembling a multisubunit coactivator complex, which probably acts by remodelling chromatin. As part of this complex it recruits p300/CBP-associated factor and CREB binding protein, and the protein itself displays histone acetyltransferase activity.
The range of receptors it coactivates is broad: steroid receptors (GR and ER), retinoid receptors (RARs and RXRs), thyroid hormone receptors (TRs), the vitamin D3 receptor (VDR) and prostanoid-responsive PPARs. NCOA3 is also involved in coactivation of the NF-kappa-B pathway through its interaction with the NFKB1 subunit, extending its role beyond classical nuclear receptor signalling. The protein is initially found in the cytoplasm and is translocated into the nucleus upon phosphorylation.
The NCOA3 gene belongs to the SRC/p160 nuclear receptor coactivator family and is grouped by HGNC with basic helix-loop-helix proteins, lysine acetyltransferases and PAS domain-containing proteins. Several transcript variants encoding different isoforms have been reported, and a polymorphic repeat region lies in the C-terminus of the encoded protein. The many aliases, including AIB1, RAC3, ACTR, p/CIP, TRAM-1, CAGH16, TNRC16, bHLHe42 and SRC-3, reflect its independent identification in several laboratories. Mouse and rat orthologs are both named Ncoa3. Related family members include NCOA1.
NCOA3 enhances hormone-dependent transcription by steroid, retinoid, thyroid hormone, vitamin D3 and PPAR receptors, making it a key subject for coactivator studies.
As a histone acetyltransferase that helps build a multisubunit coactivator complex with p300/CBP-associated factor and CREB binding protein, it is relevant to chromatin remodelling research.
NCOA3 coactivates the NF-kappa-B pathway through interaction with the NFKB1 subunit, linking nuclear receptor coactivators to NF-kappa-B regulation.
NCOA3 is initially cytoplasmic and moves into the nucleus upon phosphorylation, offering a model for studying signal-regulated nuclear translocation.
NCOA3 binds nuclear receptors directly and stimulates their transcriptional activity in a hormone-dependent way. It helps form a multisubunit coactivator complex that probably remodels chromatin, has histone acetyltransferase activity, and also coactivates the NF-kappa-B pathway through its interaction with NFKB1.
NCOA3 is also called SRC-3, SRC3, AIB1, RAC3, ACTR, p/CIP, TRAM-1, KAT13B, bHLHe42, CAGH16 and TNRC16. Several transcript variants encoding different isoforms have been described, so literature and datasheets may use any of these names for the same gene.
Yes. Orthologs named Ncoa3 exist in both mouse and rat. Human NCOA3 belongs to the SRC/p160 nuclear receptor coactivator family. Check the datasheet of any product for its validated reactivity before using it in a rodent model.
Other nuclear receptor coactivators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y6Q9; product specifications from Assay Genie datasheets.