SEMA6A
SEMA6A (semaphorin 6A) is a membrane-associated member of the semaphorin family, predicted to act in chemorepulsion and semaphorin receptor binding. It is also known as KIAA1368, SEMA6A1, SEMA, HT018 and SEMAQ. Browse Assay Genie's current range of SEMA6A research reagents below, or read on for the biology behind the target.
SEMA6A belongs to the semaphorin family and is located at the cell membrane. According to the NCBI Gene summary, it is predicted to enable chemorepellent activity, identical protein binding and semaphorin receptor binding. It is also predicted to be active in the plasma membrane and to be found in axons. These functions place SEMA6A among the guidance-type signalling proteins that shape how cells respond to cues in their environment.
The NCBI Gene summary links SEMA6A to several processes in the vasculature and in signalling control. It is involved in the cellular response to vascular endothelial growth factor stimulus, in negative regulation of cell adhesion involved in sprouting angiogenesis, and in negative regulation of signal transduction. UniProt also records a role in microbial infection: SEMA6A acts as a receptor for the P. sordellii toxin TcsL in the vascular endothelium.
The human SEMA6A gene encodes semaphorin-6A, a protein of 1030 amino acids. HGNC places it in the Semaphorins gene group. Its previous name, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A, describes the domain architecture that gave the class its name. Earlier symbols include KIAA1368, SEMA6A1, SEMA, HT018 and SEMAQ. The mouse ortholog is Sema6a, which is often used to study the protein in vivo.
SEMA6A is predicted to show chemorepellent activity and to be located in axons, making it a candidate for studying repulsive guidance cues.
SEMA6A is involved in negative regulation of cell adhesion in sprouting angiogenesis and in the cellular response to VEGF stimulus.
SEMA6A is predicted to bind semaphorin receptors and itself, and to negatively regulate signal transduction, so it suits work on semaphorin pathways.
SEMA6A acts as a receptor for the P. sordellii toxin TcsL in the vascular endothelium, which is relevant to toxin entry studies.
SEMA6A is a cell membrane semaphorin predicted to have chemorepellent activity and semaphorin receptor binding. It is involved in the response to VEGF stimulus, in negative regulation of sprouting angiogenesis adhesion and in negative regulation of signal transduction. It also serves as a receptor for TcsL toxin in vascular endothelium.
The HGNC name is semaphorin 6A, and UniProt calls the protein semaphorin-6A. Aliases and previous symbols include KIAA1368, SEMA6A1, SEMA, HT018 and SEMAQ. The earlier HGNC name described its sema, transmembrane and cytoplasmic domains. Check the datasheet of any product for its validated reactivity.
A mouse ortholog, Sema6a, is recorded for the human gene. Several SEMA6A functions in the NCBI Gene summary are described as predicted, based on Alliance of Genome Resources annotation. Check the datasheet of any product for its validated reactivity before using it in another species.
Other semaphorin family members from the class 3 to 7 groups, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H2E6; product specifications from Assay Genie datasheets.