XPO1
XPO1 (exportin 1, also known as CRM1, CRM-1 and emb) is a member of the exportin family that mediates leucine-rich nuclear export signal (NES)-dependent protein transport out of the nucleus. It also carries viral RNAs and proteins across the nuclear envelope. Browse Assay Genie's current range of XPO1 research reagents below, or read on for the biology behind the target.
XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport, moving cargo proteins from the nucleus to the cytoplasm. By controlling where its cargoes sit in the cell, it contributes to the regulation of several cellular processes. The NCBI Gene summary notes that it controls the localisation of cyclin B, MAPK and MAPKAP kinase 2, and that it also regulates NFAT and AP-1. The same summary describes a role in the export of Rev and U snRNAs.
XPO1 also features prominently in virology. UniProt annotates it as mediating the export of unspliced or incompletely spliced RNAs from the nucleus for several viruses, including HIV-1, HTLV-1 and influenza A. It interacts with, and mediates the nuclear export of, the HIV-1 Rev and HTLV-1 Rex proteins, and it is involved in HTLV-1 Rex multimerisation. This makes the exportin a common reference point for studies of viral RNA trafficking.
The XPO1 gene is cell-cycle-regulated and the protein belongs to the exportin family, which HGNC lists as the Exportins gene group. The protein is found in the cytoplasm and in the nucleus, where UniProt records it in the nucleoplasm, Cajal bodies and the nucleolus. The CRM1 name derives from earlier nomenclature, and HGNC lists previous names that refer to the yeast CRM1 homologue. Mouse and rat both carry an ortholog named Xpo1.
XPO1 mediates NES-dependent protein export, so it is a central subject for studies of how cargo localisation is controlled between nucleus and cytoplasm.
The XPO1 gene is cell-cycle-regulated and the protein controls the localisation of cyclin B, making it relevant to studies of cell cycle control.
XPO1 mediates export of unspliced viral RNAs and of HIV-1 Rev and HTLV-1 Rex, supporting research on HIV-1, HTLV-1 and influenza A.
By controlling MAPK and MAPKAP kinase 2 localisation and regulating NFAT and AP-1, XPO1 links nuclear export to signalling pathways.
XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport out of the nucleus. It controls the localisation of cyclin B, MAPK and MAPKAP kinase 2, regulates NFAT and AP-1, and exports viral RNAs and proteins such as HIV-1 Rev and HTLV-1 Rex.
CRM1 and CRM-1 are established aliases of XPO1, and emb is another listed alias. HGNC records previous names that refer to the yeast CRM1 homologue, reflecting the original nomenclature before the gene was named exportin 1 within the exportin family.
Yes. Both mouse and rat have an ortholog named Xpo1, so the protein can be studied in common rodent models. As always, check the datasheet of any product for its validated reactivity.
Other exportins, nuclear transport factors and XPO1 cargo and pathway partners with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O14980; product specifications from Assay Genie datasheets.