CDC6
CDC6 (cell division cycle 6, also known as CDC18L) is a human DNA replication factor that acts at the early steps of replication initiation. It is highly similar to Saccharomyces cerevisiae Cdc6 and also contributes to checkpoint controls that link DNA replication to mitosis. Browse Assay Genie's current range of CDC6 research reagents below, or read on for the biology behind the target.
CDC6 is involved in the initiation of DNA replication. NCBI Gene describes the protein as a regulator of the early steps of replication, and it is highly similar to yeast Cdc6, a protein essential for initiation of DNA replication in Saccharomyces cerevisiae. In addition to its role at the start of replication, CDC6 participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
The human CDC6 gene encodes the DNA replication factor CDC6 protein, which belongs to the CDC6/cdc18 family. UniProt lists its subcellular locations as nucleus and cytoplasm, and the distribution changes through the cell cycle. CDC6 localises in the nucleus during G1 but translocates to the cytoplasm at the start of S phase. This subcellular translocation is regulated by phosphorylation by Cdks.
Transcription of the CDC6 gene has been reported to respond to mitogenic signals through a mechanism involving E2F proteins, linking its expression to growth-signal control. Earlier names for the gene reflect its yeast homologue, including CDC6 cell division cycle 6 homolog (S. cerevisiae), and CDC18L is a recorded alias. The mouse ortholog is Cdc6, which makes the protein accessible to comparative cell-cycle studies.
CDC6 is involved in the initiation of DNA replication and regulates the early steps of the process, making it a core subject in replication studies.
CDC6 participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Its movement from nucleus to cytoplasm at the start of S phase is regulated by Cdk phosphorylation, a model for cell-cycle-dependent localisation.
CDC6 transcription is reported to respond to mitogenic signals through E2F proteins, connecting growth signalling to replication control.
CDC6 is involved in the initiation of DNA replication and regulates the early steps of the process. It also participates in checkpoint controls that ensure DNA replication is completed before mitosis begins. Its activity is linked to the cell cycle through Cdk-regulated phosphorylation and localisation.
The HGNC name is cell division cycle 6, and UniProt names the protein DNA replication factor CDC6. CDC18L is a recorded alias. Previous names refer to the S. cerevisiae homolog, for example CDC6 cell division cycle 6 homolog (S. cerevisiae), reflecting the yeast gene it resembles.
UniProt lists the nucleus and cytoplasm. According to NCBI Gene, CDC6 is nuclear in G1 and translocates to the cytoplasm at the start of S phase, regulated by Cdk phosphorylation. A mouse ortholog, Cdc6, exists; check the datasheet of any product for its validated reactivity.
Other CDC-family proteins, replication initiation factors and cell cycle regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q99741; product specifications from Assay Genie datasheets.