NR4A3
NR4A3 (nuclear receptor subfamily 4 group A member 3, also known as NOR1, MINOR, CSMF and CHN) is a nuclear transcription factor of the NR4 subfamily. It regulates cell proliferation, survival and differentiation, and has roles in metabolism and inflammation. Browse Assay Genie's current range of NR4A3 research reagents below, or read on for the biology behind the target.
NR4A3 is a transcriptional activator that binds regulatory elements in promoter regions in a cell- and response element-specific manner. It induces gene expression by binding as a monomer to the NR4A1 response element (NBRE, 5'-AAAAGGTCA-3') and as a homodimer to the Nur response element (NurRE) in the promoters of its target genes. It controls proliferation, survival and differentiation in many cell types. In vascular smooth muscle it acts through SKP2, CCND1 and CCND2, and it is needed for S phase entry and RB1 phosphorylation. In pancreatic type B cells it drives proliferation, while in myeloid progenitors it represses RUNX1 to limit proliferation.
The protein also supports neuronal survival, mediating CREB-induced survival and pyramidal cell survival and axonal guidance in the developing hippocampus. It contributes to semicircular canal development in the inner ear and to anterior mesoderm formation during gastrulation. In inflammation, NR4A3 mediates TNF-induced monocyte adhesion by inducing VCAM1 and ICAM1, and in activated mast cells it promotes cytokine synthesis and release while impairing degranulation. In metabolism, it inhibits AGRP expression by forming a complex with activated NR3C1 on the glucocorticoid response element. It regulates oxidative metabolism genes in skeletal muscle after catecholamine stimulation, influences SLC2A4 translocation, inhibits adipogenesis and participates in cardiac hypertrophy by activating PARP1.
The NR4A3 gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily, and multiple transcript variants encoding different isoforms have been described. Reciprocal translocations between NR4A3 and EWSR1, TAF15 or TCF12 give rise to three versions of extraskeletal myxoid chondrosarcoma. The mouse and rat orthologues are both designated Nr4a3.
NR4A3 promotes mitogen- and PDGF-induced smooth muscle proliferation through SKP2, CCND1 and CCND2, making it relevant to vascular cell cycle control.
Fusions of NR4A3 with EWSR1, TAF15 or TCF12 underlie extraskeletal myxoid chondrosarcoma, linking the gene to tumour studies.
NR4A3 modulates feeding behaviour, AGRP expression, skeletal muscle oxidative metabolism, SLC2A4 translocation and adipogenesis.
NR4A3 induces VCAM1 and ICAM1 after TNF stimulation and shapes cytokine release in activated mast cells.
NR4A3 is a nuclear transcription factor that binds the NBRE as a monomer and the NurRE as a homodimer to activate target genes. It regulates proliferation, survival and differentiation, and contributes to metabolism and inflammation across several cell types.
NR4A3 is also called NOR1, MINOR, CSMF and CHN, and was previously named nuclear receptor subfamily 4, group A, member 3. Multiple transcript variants encoding different isoforms have been reported, so check the datasheet of any product for its validated reactivity.
Reciprocal translocations joining NR4A3 to EWSR1, TAF15 or TCF12 cause three versions of extraskeletal myxoid chondrosarcoma. The gene has mouse and rat orthologues, both named Nr4a3, which are used to study its function.
Other NR4 subfamily members, nuclear receptors and co-regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92570; product specifications from Assay Genie datasheets.