HDAC6
HDAC6 (histone deacetylase 6) is a class IIB member of the histone deacetylase family that removes acetyl groups from protein substrates and represses transcription. It is also known as KIAA0901, JM21, HD6, FLJ16239, PPP1R90 and KDAC6. Browse Assay Genie's current range of HDAC6 research reagents below, or read on for the biology behind the target.
HDAC6 is a protein deacetylase. Histone acetylation and deacetylation alter chromosome structure and affect how transcription factors access DNA, and histones therefore have a critical role in transcriptional regulation, cell cycle progression and developmental events. HDAC6 possesses histone deacetylase activity and represses transcription. In the context of infection, UniProt records that HDAC6 deacetylates the SARS-CoV-2 N protein, which promotes association of the viral N protein with human G3BP1. This disrupts cellular stress granule formation and facilitates viral replication.
The HDAC6 gene encodes a member of the histone deacetylase family, assigned to the HD type 2 subfamily and, in HGNC nomenclature, to the class IIB histone deacetylases. An unusual feature of the protein is an internal duplication of two catalytic domains, which appear to function independently of each other. HGNC also places the gene in the groups of ring finger proteins and protein phosphatase 1 regulatory subunits, reflected in the alias PPP1R90.
UniProt lists a broad range of subcellular locations for HDAC6: the cytoplasm, the cytoskeleton, the nucleus, the perikaryon, dendrites, axons and cilia, as well as the centrosome and the ciliary basal body. This distribution is consistent with a protein that acts on substrates beyond chromatin. Researchers studying HDAC6 often compare it with other histone deacetylases, such as the other class II enzymes, to define its specific roles in deacetylation and transcriptional repression.
HDAC6 has histone deacetylase activity and represses transcription, making it a subject in studies of acetylation and gene regulation.
HDAC6 localises to the cytoskeleton, centrosome, ciliary basal body and cilia, so it is relevant to studies of these cellular structures.
UniProt locates HDAC6 to the perikaryon, dendrites and axons, supporting its study in neuronal compartments.
HDAC6 deacetylates the SARS-CoV-2 N protein, promoting G3BP1 association, stress granule disruption and viral replication.
HDAC6 is a protein deacetylase with histone deacetylase activity that represses transcription. It contains two catalytic domains that appear to act independently. It also deacetylates the SARS-CoV-2 N protein, promoting its association with G3BP1, disrupting stress granule formation and facilitating viral replication.
The HGNC name is histone deacetylase 6, and UniProt calls the protein protein deacetylase HDAC6. Aliases include KIAA0901, JM21, HD6, FLJ16239, PPP1R90 and KDAC6. The PPP1R90 alias reflects its HGNC grouping among protein phosphatase 1 regulatory subunits.
Yes. Mouse and rat both have an ortholog named Hdac6, so the gene can be studied in common rodent models. Human HDAC6 belongs to the class IIB histone deacetylases. Check the datasheet of any product for its validated reactivity.
Other histone deacetylases across the class I, class II and class IV groups, for comparison with HDAC6.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UBN7; product specifications from Assay Genie datasheets.