SORCS1
SORCS1 (sortilin related VPS10 domain containing receptor 1) is a membrane protein of the VPS10-related sortilin family, SORCS subfamily. It is one of the vacuolar protein sorting 10 (VPS10) domain-containing receptors, which are strongly expressed in the central nervous system. Browse Assay Genie's current range of SORCS1 research reagents below, or read on for the biology behind the target.
SORCS1 is a member of the vacuolar protein sorting 10 (VPS10) domain-containing receptor family. The family takes its name from the yeast carboxypeptidase Y sorting receptor Vps10, and the SORCS1 protein belongs to the VPS10-related sortilin family, SORCS subfamily. UniProt annotates SORCS1 as a membrane protein. No functional annotation is currently recorded in UniProt for this protein, so research on its activity relies largely on its family relationships and expression pattern.
The SORCS1 gene shares a characteristic architecture with its relatives. Family genes have many exons, yet coding sequences are usually under 3700 nt. Very large introns typically separate the exons that encode the VPS10 domain, while the remaining exons are separated by much smaller introns. According to the NCBI Gene summary, these genes are strongly expressed in the central nervous system, which makes them of particular interest to neuroscientists studying receptor trafficking and sorting.
Of the five family members, two (sortilin and sortilin-related receptor) are synthesised as preproproteins. It is not yet known whether the protein encoded by the SORCS1 gene is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. The mouse ortholog is Sorcs1, which allows comparative work in rodent models. HGNC also records the earlier name sortilin-related VPS10 domain containing receptor 1.
SORCS1 belongs to a gene family strongly expressed in the central nervous system, making it a relevant target in studies of neural protein sorting.
As a VPS10 domain-containing receptor related to the yeast Vps10 sorting receptor, SORCS1 is studied within the wider context of receptor-mediated sorting.
SORCS1 sits in the SORCS subfamily of the VPS10-related sortilin family, supporting comparison with sortilin and sortilin-related receptor.
Alternatively spliced transcript variants encode different isoforms, so SORCS1 is a useful subject for transcript and expression analysis.
SORCS1 is a membrane receptor of the VPS10 domain-containing family, named after the yeast carboxypeptidase Y sorting receptor Vps10. UniProt holds no detailed function annotation for it. The NCBI Gene summary notes that family members are strongly expressed in the central nervous system.
The HGNC full name is sortilin related VPS10 domain containing receptor 1, and UniProt lists it as VPS10 domain-containing receptor SorCS1. No alias symbols are recorded. Alternatively spliced transcript variants encoding different isoforms have been identified for the SORCS1 gene.
A mouse ortholog, Sorcs1, is recorded, so rodent models can be used for comparative work. SORCS1 is one of five VPS10 domain-containing receptors in its family, alongside sortilin and sortilin-related receptor. Check the datasheet of any product for its validated reactivity.
Other VPS10 domain-containing receptors, including sortilin and SORCS subfamily members, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8WY21; product specifications from Assay Genie datasheets.