IRAK3
IRAK3, also known as IRAK-M, is a putative inactive protein kinase of the interleukin-1 receptor-associated kinase family. It regulates signalling downstream of IL-1 receptor and Toll-like receptors, acting as a negative regulator of Toll-like receptor signalling. Browse Assay Genie's current range of IRAK3 research reagents below, or read on for the biology behind the target.
IRAK3 is a putative inactive protein kinase that regulates signalling downstream of immune receptors, including IL1R and Toll-like receptors. It inhibits the dissociation of IRAK1 and IRAK4 from the Toll-like receptor signalling complex, either by inhibiting the phosphorylation of IRAK1 and IRAK4 or by stabilising the receptor complex. In this way it restrains signal transmission rather than driving it. In IL-33-induced lung inflammation, IRAK3 positively regulates the expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells.
The IRAK3 gene encodes a member of the interleukin-1 receptor-associated kinase protein family, whose members are essential components of the Toll/IL-R immune signal transduction pathways. The protein is primarily expressed in monocytes and macrophages and is found in the cytoplasm and nucleus. It belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily. HGNC classifies it among the pseudokinases, the IRAK family and the microRNA protein coding host genes. Alternate splicing of the IRAK3 gene results in multiple transcript variants. A mouse ortholog, Irak3, is recognised.
IRAK3 is also known as IRAK-M, and its previous name was interleukin-1 receptor-associated kinase 3. Mutations in the gene are associated with susceptibility to asthma. Together with IRAK1, IRAK2 and IRAK4, IRAK3 is a reference point for studying how innate immune signalling is initiated and limited.
IRAK3 negatively regulates Toll-like receptor signalling, making it a key subject for studying how innate immune responses are restrained.
The protein is primarily expressed in monocytes and macrophages, where it functions as a negative regulator of Toll-like receptor signalling.
IRAK3 inhibits dissociation of IRAK1 and IRAK4 from the receptor complex, which is relevant to studies of IRAK phosphorylation and complex stability.
Mutations in IRAK3 are associated with asthma susceptibility, and it influences IL6, CSF3, CXCL2 and CCL5 expression in IL-33-driven lung inflammation.
IRAK3 is a putative inactive kinase that regulates signalling downstream of IL1R and Toll-like receptors. It inhibits the dissociation of IRAK1 and IRAK4 from the receptor complex, and functions as a negative regulator of Toll-like receptor signalling, mainly in monocytes and macrophages.
Yes. IRAK-M is an alias of IRAK3, whose HGNC name is interleukin 1 receptor associated kinase 3. Alternate splicing of the gene produces multiple transcript variants. It is one of the IRAK family members alongside IRAK1, IRAK2 and IRAK4.
NCBI Gene reports that mutations in IRAK3 are associated with susceptibility to asthma. A mouse ortholog, Irak3, exists, and check the datasheet of any product for its validated reactivity.
Other IRAK family members that act alongside IRAK3 in Toll-like receptor and IL-1 receptor signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y616; product specifications from Assay Genie datasheets.