RAB5B
RAB5B is a Rab-family small GTPase that regulates intracellular membrane trafficking, with a defined role in early endocytic transport. It is also known as Ras-related protein Rab-5B and belongs to the RAB, member RAS oncogene GTPase gene group. Browse Assay Genie's current range of RAB5B research reagents below, or read on for the biology behind the target.
Rab proteins are key regulators of intracellular membrane trafficking, acting from the formation of transport vesicles through to their fusion with target membranes. RAB5B cycles between an inactive GDP-bound form and an active GTP-bound form. In the GTP-bound state it recruits sets of downstream effectors to membranes, and these effectors are directly responsible for vesicle formation, movement, tethering and fusion.
RAB5B is involved in early endocytic trafficking. It is required for the recruitment of EEA1 to early endosomes, and for the endocytosis of EGF and transferrin and their trafficking through early endosomes. Annotated molecular functions include G protein activity, GDP binding and GTP-dependent protein binding, and the protein is linked to endocytosis, endosomal transport and transport from the plasma membrane to the endosome.
The RAB5B protein belongs to the small GTPase superfamily and the Rab family, and is classed by HGNC in the RAB, member RAS oncogene GTPases group. Its subcellular locations include the cell membrane, the early endosome membrane and the melanosome, and it has also been reported in extracellular exosomes. The mouse ortholog is Rab5b. Researchers studying the RAB5B gene or protein often examine it alongside other Rab5 family members and endocytic pathway markers.
RAB5B is involved in early endocytic trafficking and plasma membrane to endosome transport, making it relevant to studies of how cargo enters the cell.
RAB5B is required for EEA1 recruitment to early endosomes, linking this GTPase to the organisation and function of that compartment.
RAB5B is required for EGF and transferrin endocytosis and their trafficking through early endosomes, supporting work on receptor internalisation.
As a Rab GTPase cycling between GDP- and GTP-bound states, RAB5B is a model for studying effector recruitment in vesicle formation, tethering and fusion.
RAB5B is a small GTPase that regulates membrane trafficking. In its active GTP-bound form it recruits downstream effectors to membranes. It is involved in early endocytic trafficking, is required for EEA1 recruitment to early endosomes, and is needed for EGF and transferrin endocytosis.
The HGNC full name is RAB5B, member RAS oncogene family, and the UniProt protein name is Ras-related protein Rab-5B. No other aliases or previous symbols are listed. As a GTPase it is assigned EC 3.6.5.2.
A mouse ortholog, Rab5b, is recorded for the human gene. RAB5B belongs to the Rab family of the small GTPase superfamily, whose members regulate membrane trafficking. Please check the datasheet of any product for its validated reactivity.
Other Rab5 family members, endosomal Rab GTPases and membrane-trafficking regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P61020; product specifications from Assay Genie datasheets.