AMOTL1
AMOTL1 (angiomotin like 1, also known as JEAP) is a peripheral membrane protein of the angiomotin family and a component of tight junctions. It inhibits Wnt/beta-catenin signalling and helps control paracellular permeability and cell polarity. Browse Assay Genie's current range of AMOTL1 research reagents below, or read on for the biology behind the target.
AMOTL1 is a peripheral membrane protein that is a component of tight junctions (TJs). TJs form an apical junctional structure in epithelial and related cell layers, where they control paracellular permeability and maintain cell polarity. As a TJ-associated protein, AMOTL1 sits at the interface between junctional architecture and intracellular signalling.
In signalling terms, AMOTL1 inhibits the Wnt/beta-catenin pathway. The proposed mechanism is that it recruits CTNNB1 (beta-catenin) to recycling endosomes, which prevents translocation of beta-catenin to the nucleus. This is described as probable rather than fully established, so the precise route of beta-catenin sequestration remains a point to confirm experimentally.
The AMOTL1 gene encodes angiomotin-like protein 1, a member of the angiomotin family, and the protein is related to angiomotin, an angiostatin-binding protein that regulates endothelial cell migration and capillary formation. JEAP is a recognised alias. Two transcript variants encoding different isoforms have been reported. The mouse ortholog is designated Amotl1, and AMOTL2 is another family-related target that researchers often study alongside it. Researchers studying AMOTL1 with an AMOTL1 antibody or AMOTL1 ELISA kit are typically interested in junction biology and Wnt pathway control.
AMOTL1 is a tight junction component, making it relevant to studies of paracellular permeability and the apical junctional structure.
As part of tight junctions, AMOTL1 contributes to the maintenance of cell polarity, a core question in epithelial organisation.
AMOTL1 inhibits Wnt/beta-catenin signalling, probably by directing CTNNB1 to recycling endosomes and away from the nucleus.
Related to angiomotin, which regulates endothelial cell migration and capillary formation, AMOTL1 is a useful member for comparative family research.
AMOTL1 is a peripheral membrane protein found in tight junctions, which control paracellular permeability and maintain cell polarity. It also inhibits Wnt/beta-catenin signalling, probably by recruiting CTNNB1 to recycling endosomes and so preventing its translocation to the nucleus.
AMOTL1 stands for angiomotin like 1; the UniProt name is angiomotin-like protein 1, and JEAP is a known alias. RefSeq reports two transcript variants of the AMOTL1 gene that encode different isoforms of the protein.
AMOTL1 belongs to the angiomotin family and is related to angiomotin, an angiostatin-binding protein that regulates endothelial cell migration and capillary formation. The mouse ortholog is Amotl1; check the datasheet of any product for its validated reactivity.
Angiomotin family members and other tight junction and Wnt signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8IY63; product specifications from Assay Genie datasheets.