TAS1R2
TAS1R2 (taste 1 receptor member 2, also known as T1R2, TR2 and GPR71) is a G protein-coupled receptor and a key component of the sweet taste receptor. It pairs with TAS1R3 to recognise natural and synthetic sweeteners. Browse Assay Genie's current range of TAS1R2 research reagents below, or read on for the biology behind the target.
TAS1R2 is a key component of the sweet taste receptor. Together with TAS1R3 it forms the sweet taste receptor, which recognises diverse natural and synthetic sweeteners. The receptor has lower affinity for natural sugars than for synthetic sweeteners. TAS1R2 functions as a G protein-coupled receptor and signals primarily through the gustducin heterotrimer. In Gene Ontology terms, it contributes to sweet taste receptor activity, is part of the sweet taste receptor complex, and is involved in the detection of chemical stimuli underlying sensory perception of sweet taste.
The TAS1R2 protein, taste receptor type 1 member 2, localises to the cell membrane. It belongs to the G protein-coupled receptor 3 family and the TAS1R subfamily, and the HGNC places the TAS1R2 gene in the gene group of taste 1 receptors. Mouse and rat orthologs are both designated Tas1r2, which allows the receptor to be studied in rodent models.
The gene has been known under several names: T1R2, TR2 and GPR71, with previous full names including G protein-coupled receptor 71 and taste receptor, type 1, member 2. NCBI Gene also lists a role for TAS1R2 in positive regulation of cytokinesis, based on Alliance of Genome Resources annotation. Researchers studying sweet taste signalling often examine TAS1R2 alongside TAS1R3 and related taste receptors such as the bitter receptor TAS2R38.
TAS1R2 and TAS1R3 form the sweet taste receptor, making TAS1R2 central to studies of how sweet stimuli are detected and transduced.
The receptor recognises diverse natural and synthetic sweeteners, with lower affinity for natural sugars than for synthetic ones, which is relevant to sweetener research.
TAS1R2 acts as a G protein-coupled receptor signalling primarily through the gustducin heterotrimer, a model for taste-cell signal transduction.
Tas1r2 orthologs in mouse and rat support cross-species comparison of sweet taste receptor function and chemosensory perception.
TAS1R2 is a key component of the sweet taste receptor. It combines with TAS1R3 to recognise natural and synthetic sweeteners, and acts as a G protein-coupled receptor that signals primarily through the gustducin heterotrimer.
TAS1R2 is also called T1R2, TR2 and GPR71. Earlier names include G protein-coupled receptor 71 and taste receptor, type 1, member 2. The UniProt entry is titled taste receptor type 1 member 2.
Yes. Mouse and rat both carry a Tas1r2 ortholog. TAS1R2 belongs to the G protein-coupled receptor 3 family, TAS1R subfamily. Check the datasheet of any product for its validated reactivity.
Other taste receptors and chemosensory GPCR targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TE23; product specifications from Assay Genie datasheets.