CRMP1
CRMP1 (collapsin response mediator protein 1, also known as DRP-1 or DPYSL1) is a cytosolic phosphoprotein expressed exclusively in the nervous system. It is needed for class 3 semaphorin signalling and the cytoskeletal remodelling that guides developing axons. Browse Assay Genie's current range of CRMP1 research reagents below, or read on for the biology behind the target.
CRMP1 is necessary for signalling by class 3 semaphorins and for the cytoskeletal remodelling that follows. It plays a role in axon guidance. In this process it acts downstream of SEMA3A to promote the dissociation of FLNA from F-actin. This rearranges the actin cytoskeleton and leads to collapse of the growth cone. CRMP1 is also involved in invasive growth and cell migration, and it may participate in cytokinesis.
The CRMP1 gene encodes a member of a family of cytosolic phosphoproteins that are expressed exclusively in the nervous system. The protein is thought to be part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing of the CRMP1 gene gives rise to multiple transcript variants. In UniProt, the protein is annotated in the cytoplasm, including the cytoskeleton, centrosome, spindle, growth cone and perikaryon. Mouse and rat both have a Crmp1 ortholog.
The protein is also called dihydropyrimidinase-related protein 1, which reflects its place in the metallo-dependent hydrolases superfamily and the hydantoinase/dihydropyrimidinase family. HGNC places the gene in the M38 metallopeptidases group. The aliases DRP-1 and DPYSL1 are both in use in the literature. Researchers studying neural development, growth cone behaviour and semaphorin-driven cytoskeletal change often work with CRMP1 antibody, CRMP1 ELISA kit and CRMP1 protein reagents.
CRMP1 is involved in axon guidance, acting downstream of SEMA3A to help direct growth cone behaviour in developing neurons.
CRMP1 is necessary for class 3 semaphorin signalling and is thought to be part of the semaphorin pathway.
CRMP1 promotes FLNA dissociation from F-actin, leading to actin rearrangement and growth cone collapse.
CRMP1 is involved in invasive growth and cell migration, and may participate in cytokinesis.
CRMP1 is necessary for class 3 semaphorin signalling and the cytoskeletal remodelling that follows. In axon guidance it acts downstream of SEMA3A to promote FLNA dissociation from F-actin, causing growth cone collapse. It is also involved in invasive growth and cell migration, and may participate in cytokinesis.
CRMP1 stands for collapsin response mediator protein 1. UniProt lists it as dihydropyrimidinase-related protein 1, and other aliases are DRP-1 and DPYSL1. The NCBI summary notes that alternative splicing produces multiple transcript variants of the CRMP1 gene.
Mouse and rat each have a Crmp1 ortholog. The NCBI Gene summary describes the CRMP family as cytosolic phosphoproteins expressed exclusively in the nervous system. Check the datasheet of any product for its validated reactivity.
Semaphorin pathway components, other CRMP family members and cytoskeletal regulators studied alongside CRMP1.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14194; product specifications from Assay Genie datasheets.