PRKACG
PRKACG (protein kinase cAMP-activated catalytic subunit gamma, also known as PKACg) is the gamma form of the catalytic subunit of cyclic AMP-dependent protein kinase, or PKA. It phosphorylates a large number of substrates in the cytoplasm and the nucleus. Browse Assay Genie's current range of PRKACG research reagents below, or read on for the biology behind the target.
PRKACG encodes the gamma form of the catalytic subunit of cyclic AMP-dependent protein kinase (PKA). The PKA holoenzyme consists of two catalytic subunits and a regulatory subunit dimer. As a catalytic subunit, the PRKACG protein is a serine/threonine kinase (EC 2.7.11.11) that phosphorylates a large number of substrates in the cytoplasm and the nucleus.
UniProt places the protein in the protein kinase superfamily, within the AGC Ser/Thr protein kinase family and the cAMP subfamily. HGNC classifies the gene within the protein kinase A subunits group and the protein kinase A family. A subcellular location has not been annotated in UniProt, although the function annotation describes activity towards both cytoplasmic and nuclear substrates.
The PRKACG gene has an unusual structure: it is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. This origin helps explain its relationship to the other PKA catalytic subunits. Previous HGNC names for the gene include protein kinase, cAMP-dependent, catalytic, gamma, and protein kinase, cAMP-dependent, gamma catalytic subunit. Researchers studying cAMP signalling, kinase substrates or PKA subunit composition will find the gamma subunit a distinct member of the family to examine alongside its relatives.
PRKACG is a catalytic subunit of PKA, the cyclic AMP-dependent kinase, making it relevant to studies of how cAMP signals are transduced.
The protein phosphorylates many substrates in the cytoplasm and nucleus, so it is of interest when mapping PKA-dependent phosphorylation.
The PKA holoenzyme contains two catalytic subunits and a regulatory dimer, and PRKACG represents the gamma catalytic form.
As an intronless gene thought to derive by retrotransposition from the alpha catalytic subunit gene, PRKACG is a case study in kinase gene evolution.
PRKACG encodes the gamma catalytic subunit of cyclic AMP-dependent protein kinase (PKA). The enzyme is a serine/threonine kinase, EC 2.7.11.11, and phosphorylates a large number of substrates in the cytoplasm and the nucleus.
PRKACG is also called PKACg. HGNC lists the full name as protein kinase cAMP-activated catalytic subunit gamma, and UniProt calls the protein cAMP-dependent protein kinase catalytic subunit gamma. Older names include protein kinase, cAMP-dependent, catalytic, gamma.
The PRKACG gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. The protein belongs to the AGC Ser/Thr protein kinase family, cAMP subfamily. Check the datasheet of any product for its validated reactivity.
Other PKA catalytic and regulatory subunits and related cAMP signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P22612; product specifications from Assay Genie datasheets.