ETV1
ETV1 (ETS variant transcription factor 1, also known as ER81) is a nuclear transcriptional activator of the ETS family. It binds DNA sequences containing the consensus 5'-CGGA[AT]-3' and is required for olfactory dopaminergic neuron differentiation. Browse Assay Genie's current range of ETV1 research reagents below, or read on for the biology behind the target.
ETV1 is a transcriptional activator that binds DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. It is required for the differentiation of olfactory dopaminergic neurons and may directly activate expression of tyrosine hydroxylase (TH). The protein is localised to the nucleus, consistent with its role in regulating gene expression.
The ETV1 gene encodes a member of the ETS (E twenty-six) family of transcription factors. ETS proteins regulate many target genes that modulate biological processes such as cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain, which in ETV1 sits in the C-terminal region. The ETV1 protein also carries a conserved short acidic transactivation domain (TAD) in its N-terminal region. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
ETV1 was previously named ets variant gene 1 and ETS variant 1, and is also known by the alias ER81. The gene is involved in chromosomal translocations that produce several fusion proteins, including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners in prostate cancer. In addition to rearrangement, ETV1 is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumour, which makes it a frequent subject in cancer biology. The mouse ortholog is Etv1.
ETV1 is required for olfactory dopaminergic neuron differentiation and may directly activate tyrosine hydroxylase expression.
ETV1 forms fusions with at least 10 partners in prostate cancer and is overexpressed in this tumour type.
The EWS-ETV1 fusion occurs in Ewing sarcoma, and ETV1 overexpression is reported in melanoma and gastrointestinal stromal tumour.
As an ETS family activator with a defined DNA consensus, ETV1 is used to study control of growth, migration and differentiation genes.
ETV1 is a nuclear transcriptional activator that binds DNA containing the consensus 5'-CGGA[AT]-3'. It is required for olfactory dopaminergic neuron differentiation and may directly activate tyrosine hydroxylase (TH) expression. As an ETS family member, it contributes to regulation of genes involved in growth, migration and differentiation.
ETV1 is the approved symbol for ETS variant transcription factor 1, also called ETS translocation variant 1 and by the alias ER81. Earlier names include ets variant gene 1 and ETS variant 1. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
ETV1 is involved in chromosomal translocations, including EWS-ETV1 in Ewing sarcoma and multiple partners in prostate cancer. It is also overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumour. The mouse ortholog is Etv1; check the datasheet of any product for its validated reactivity.
Other ETS variant transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P50549; product specifications from Assay Genie datasheets.