OAS1
OAS1 (2'-5'-oligoadenylate synthetase 1, also known as OIAS, OIASI and IFI-4) is an interferon-induced enzyme that synthesises 2',5'-oligoadenylates (2-5As). It plays a key role in the innate cellular antiviral response. Browse Assay Genie's current range of OAS1 research reagents below, or read on for the biology behind the target.
OAS1 is an interferon-induced enzyme that synthesises 2',5'-oligoadenylates (2-5As). It has a key role in the innate cellular antiviral response, and it has also been implicated in other cellular processes such as cell growth and apoptosis. The enzyme is assigned EC 2.7.7.84 and belongs to the 2-5A synthase family.
UniProt records the OAS1 protein in several locations: cytoplasm, mitochondrion, nucleus, microsome, endoplasmic reticulum and secreted. One annotation notes that a form which is not prenylated at the C-terminus is diffusely localised and unable to initiate a detectable block to SARS-CoV-2 replication. Alternative splicing of the OAS1 gene gives multiple transcript variants with different enzymatic activities.
The gene sits in a cluster of related genes on chromosome 12, alongside other members of the 2'-5'-oligoadenylate synthetase family such as OAS2, OAS3 and OASL. Earlier names include 2',5'-oligoadenylate synthetase 1 (40-46 kD) and 2'-5'-oligoadenylate synthetase 1, 40/46kDa. Polymorphisms in OAS1 have been associated with susceptibility to viral infection, including SARS-CoV-2, and with type 1 diabetes mellitus.
OAS1 is an interferon-induced enzyme that makes 2-5As and plays a key role in the innate cellular antiviral response.
Polymorphisms in OAS1 have been associated with susceptibility to SARS-CoV-2, and a non-prenylated form was unable to block viral replication.
OAS1 has been implicated in cellular processes beyond antiviral defence, including cell growth and apoptosis.
Polymorphisms in the OAS1 gene have been associated with susceptibility to type 1 diabetes mellitus.
OAS1 is an interferon-induced enzyme that synthesises 2',5'-oligoadenylates (2-5As). It has a key role in the innate cellular antiviral response and has also been implicated in cell growth and apoptosis.
OAS1 is also called OIAS, OIASI and IFI-4, and was previously named 2'-5'-oligoadenylate synthetase 1, 40/46kDa. Alternative splicing produces multiple transcript variants with different enzymatic activities.
Polymorphisms in the OAS1 gene have been associated with susceptibility to viral infection, including SARS-CoV-2, and with type 1 diabetes mellitus. The rat ortholog is Oas1a; check the datasheet of any product for its validated reactivity.
Other members of the 2'-5'-oligoadenylate synthetase family that sit in the same gene cluster as OAS1.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P00973; product specifications from Assay Genie datasheets.