PLEK
PLEK (pleckstrin, also known as P47 and PLEK1) is the major protein kinase C substrate of platelets. It binds phosphatidylinositol-3,4-bisphosphate and takes part in G protein-coupled receptor and integrin-mediated signalling. Browse Assay Genie's current range of PLEK research reagents below, or read on for the biology behind the target.
PLEK, or pleckstrin, is described in UniProt as the major protein kinase C substrate of platelets. Its functions include binding to protein kinase C, binding to phosphatidylinositol-3,4-bisphosphate and forming homodimers. Through these activities it is linked to several signalling processes, including G protein-coupled receptor signalling, integrin-mediated signalling and the positive regulation of supramolecular fibre organisation.
The PLEK protein is located in the cytoplasm and at the ruffle membrane, according to the NCBI Gene summary. The PLEK gene is assigned by HGNC to the groups of pleckstrin homology domain containing proteins and DEP domain containing proteins. The pleckstrin homology domain is the feature that gives the family its name. Mouse and rat each have an ortholog named Plek, so the protein can be studied in common rodent models.
The gene is also known by the aliases P47 and PLEK1. Because PLEK is a phosphorylation target of protein kinase C and is connected to lipid binding and receptor signalling, it is a useful point of reference for work on how signals at the membrane are passed to the cytoskeleton. Researchers studying PLEK may also look at other pleckstrin homology domain proteins, such as PLEKHA8 and PLEKHO1.
PLEK is the major protein kinase C substrate of platelets, making it a central protein for studying kinase signalling in these cells.
PLEK is involved in integrin-mediated signalling, which makes it relevant to studies of how cells respond to adhesion cues.
PLEK is involved in the G protein-coupled receptor signalling pathway and binds protein kinase C.
PLEK binds phosphatidylinositol-3,4-bisphosphate, localises to ruffle membranes and positively regulates supramolecular fibre organisation.
PLEK is the major protein kinase C substrate of platelets. It binds protein kinase C and phosphatidylinositol-3,4-bisphosphate, can form homodimers, and is involved in G protein-coupled receptor and integrin-mediated signalling and in the positive regulation of supramolecular fibre organisation.
The HGNC-approved name is pleckstrin. PLEK is also known as P47 and PLEK1. When searching the literature, it helps to try all of these names, as older papers often use P47 for the PLEK protein.
Yes. Both mouse and rat have an ortholog named Plek, which allows PLEK biology to be studied in rodent models. Check the datasheet of any product for its validated reactivity.
Other pleckstrin homology domain containing proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P08567; product specifications from Assay Genie datasheets.