NCOR2
NCOR2 (nuclear receptor corepressor 2, also known as SMRT, SMRTE, TRAC-1, CTG26 and TNRC14) is a nuclear corepressor that mediates transcriptional silencing of certain target genes. It acts as part of a multisubunit complex that includes histone deacetylases. Browse Assay Genie's current range of NCOR2 research reagents below, or read on for the biology behind the target.
NCOR2 encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The protein acts as part of a multisubunit complex that includes histone deacetylases. These enzymes modify chromatin structure, and through this mechanism the complex prevents basal transcriptional activity of target genes. NCOR2 is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors, and it belongs to the N-CoR nuclear receptor corepressors family.
The NCOR2 gene is found at 12q24.31 and the protein localises to the nucleus. HGNC places it in two gene groups: Myb/SANT domain containing proteins, and NCoR/SMRT transcriptional repression complex subunits. The latter group also includes NCOR1, its closest partner in the NCoR/SMRT complex. The mouse ortholog is Ncor2. Alternative splicing produces multiple transcript variants that encode different isoforms. UniProt notes that isoform 1 and isoform 4 have different affinities for different nuclear receptors, so isoform identity is relevant when interpreting experiments on the NCOR2 protein.
The protein is widely known as SMRT, and the symbols SMRTE, TRAC-1, CTG26 and TNRC14 are also used. HGNC lists the former name as nuclear receptor co-repressor 2. Aberrant expression of the NCOR2 gene is associated with certain cancers, which makes it a point of interest in studies of transcriptional regulation and disease.
NCOR2 mediates silencing of certain target genes, so it is a core subject in studies of how corepressor complexes control transcription.
As a thyroid hormone- and retinoic acid receptor-associated corepressor, NCOR2 is studied in nuclear receptor signalling.
NCOR2 works in a complex with histone deacetylases that modify chromatin structure and prevent basal transcription of target genes.
Aberrant NCOR2 expression is associated with certain cancers, which makes it relevant to studies of transcriptional dysregulation in disease.
NCOR2 is a nuclear receptor corepressor that mediates transcriptional silencing of certain target genes. It acts within a multisubunit complex containing histone deacetylases, which modify chromatin structure and prevent basal transcriptional activity of target genes.
Yes. SMRT is the best-known alias of NCOR2; others include SMRTE, TRAC-1, CTG26 and TNRC14. Alternative splicing gives multiple transcript variants and isoforms. UniProt notes that isoform 1 and isoform 4 have different affinities for different nuclear receptors.
Aberrant expression of the NCOR2 gene is associated with certain cancers. The mouse ortholog is Ncor2. Check the datasheet of any product for its validated reactivity before using it in a given species.
NCOR1, the partner corepressor in the NCoR/SMRT transcriptional repression complex, has related products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y618; product specifications from Assay Genie datasheets.