CD28
CD28 is a T-cell-specific surface glycoprotein that is essential for T-cell proliferation and survival, cytokine production and T-helper type-2 development. It was previously named CD28 antigen (Tp44) and belongs to the CD molecule group. Browse Assay Genie's current range of CD28 research reagents below, or read on for the biology behind the target.
CD28 is a glycoprotein found on the surface of T-cells. According to UniProt, it enhances CD40L-mediated activation of NF-kappa-B and of the kinases MAPK8 and PAK2 in T-cells. The NCBI Gene summary describes the protein as essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development, which makes it a central subject in studies of T-cell activation and function.
The human CD28 gene encodes a protein localised to the cell membrane and cell surface. HGNC classifies it within the CD molecules, the V-set domain containing group and the Ig-like cell adhesion molecule family. Several alternatively spliced transcript variants encoding different isoforms have been reported for the gene, so researchers should consider which form a given experiment addresses when working with a CD28 antibody, CD28 ELISA kit or recombinant CD28 protein.
The approved HGNC name is CD28 molecule, and the previous name was CD28 antigen (Tp44). Mouse and rat both carry a Cd28 ortholog, which allows the biology of this receptor to be explored in common rodent models as well as in human systems. Its role in T-cell survival, cytokine production and signalling to NF-kappa-B and MAPK8 places CD28 at the centre of work on T-cell immunology.
CD28 is essential for T-cell proliferation and survival, so it is a standard focus when studying how T-cells respond to stimulation.
The NCBI Gene summary links CD28 to cytokine production, making it relevant to studies of T-cell effector output.
CD28 contributes to T-helper type-2 development, supporting research into how T-helper subsets are established.
CD28 enhances CD40L-mediated activation of NF-kappa-B, MAPK8 and PAK2 in T-cells, offering a route into intracellular signalling analysis.
CD28 is a T-cell surface glycoprotein essential for T-cell proliferation and survival, cytokine production and T-helper type-2 development. UniProt also reports that it enhances CD40L-mediated activation of NF-kappa-B and the kinases MAPK8 and PAK2 in T-cells.
HGNC lists the approved name as CD28 molecule, with the previous name CD28 antigen (Tp44). UniProt calls the protein T-cell-specific surface glycoprotein CD28. The CD28 gene has several alternatively spliced transcript variants that encode different isoforms.
Yes. Both mouse and rat have a Cd28 ortholog, so the receptor can be studied in rodent models as well as in human samples. Species reactivity differs between reagents, so check the datasheet of any product for its validated reactivity.
Other CD molecules and immune cell surface markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P10747; product specifications from Assay Genie datasheets.