HDAC10
HDAC10 (histone deacetylase 10, also known as DKFZP761B039) is a class IIB member of the histone deacetylase family that acts mainly as a polyamine deacetylase. It prefers N(8)-acetylspermidine as a substrate and has been linked to autophagy and DNA repair. Browse Assay Genie's current range of HDAC10 research reagents below, or read on for the biology behind the target.
HDAC10 is a polyamine deacetylase (PDAC). It acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Its activity toward N(1),N(8)-diacetylspermidine is attenuated, and activity toward N(1)-acetylspermidine is very low, if any. Histone deacetylase activity has been observed in vitro, and HDAC10 has also been shown to be involved in MSH2 deacetylation. However, the physiological relevance of its protein and histone deacetylase activity is unclear and could be very weak.
The HDAC10 gene encodes a protein that belongs to the histone deacetylase family, HD type 2 subfamily, and HGNC places it in the class IIB histone deacetylases. Members of the family deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure and plays an important role in transcriptional regulation, cell cycle progression and developmental events. UniProt records HDAC10 in both the cytoplasm and the nucleus, and alternatively spliced transcript variants encoding different isoforms have been found for the gene.
Beyond deacetylation, HDAC10 may play a role in promoting the late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. It may also play a role in homologous recombination and may promote DNA mismatch repair. These roles make HDAC10 a useful target for studies of polyamine metabolism, autophagy and genome maintenance, and for comparison with other members of the HDAC family such as HDAC6.
HDAC10 deacetylates N(8)-acetylspermidine, acetylcadaverine and acetylputrescine, making it a focus for studies of acetylated polyamine turnover.
HDAC10 may promote late-stage autophagy, possibly autophagosome-lysosome fusion or lysosomal exocytosis, in neuroblastoma cells.
HDAC10 may play a role in homologous recombination and may promote DNA mismatch repair, including involvement in MSH2 deacetylation.
As a histone deacetylase family member, HDAC10 is relevant to chromatin structure, transcriptional regulation, cell cycle progression and development.
HDAC10 is mainly a polyamine deacetylase, acting preferentially on N(8)-acetylspermidine and also on acetylcadaverine and acetylputrescine. Histone deacetylase activity has been seen in vitro, but its physiological relevance is unclear. It may also promote late-stage autophagy and DNA mismatch repair.
HDAC10 is the approved symbol for histone deacetylase 10, and DKFZP761B039 is a listed alias. UniProt names the protein polyamine deacetylase HDAC10. NCBI reports that alternatively spliced transcript variants encoding different isoforms have been found for the gene.
Orthologues of the HDAC10 gene exist in mouse and rat, both named Hdac10. This allows comparative work in rodent systems, but check the datasheet of any product for its validated reactivity.
Other histone deacetylases across classes I, II and IV, including the class IIB partner HDAC6, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q969S8; product specifications from Assay Genie datasheets.