HMG20B
HMG20B (high mobility group 20B, also known as BRAF35, SOXL, HMGX2, SMARCE1r, BRAF25 and HMGXB2) is a nuclear, chromosome-associated protein of the non-canonical high mobility group. It is required for G2 phase progression and for CoREST-mediated repression of neuronal genes. Browse Assay Genie's current range of HMG20B research reagents below, or read on for the biology behind the target.
HMG20B is a chromatin-associated protein that acts in two linked processes: cell cycle control and transcriptional repression. UniProt annotates it as required for correct progression through G2 phase and for entry into mitosis. It is also required for repression of neuronal-specific gene promoters mediated by RCOR1 (CoREST), which places it within the CoREST complex.
The HMG20B gene encodes a nuclear protein that localises to chromosomes. The NCBI Gene summary describes it as predicted to enable DNA binding and to be involved in regulation of gene expression, and it is located in the nucleoplasm. The same summary lists predicted roles upstream of or within negative regulation of protein sumoylation, positive regulation of neuron differentiation and skeletal muscle cell differentiation. These annotations are predictions, so experimental work is needed to confirm them in a given system. A mouse ortholog, Hmg20b, is recognised, which allows the gene to be studied in murine models.
HGNC classifies HMG20B in the non-canonical high mobility group and among the CoREST complex subunits. The name has changed over time: it was previously listed as high-mobility group 20B, and the protein is also known as BRAF35, SOXL, HMGX2, SMARCE1r, BRAF25 and HMGXB2. The UniProt protein name, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related, reflects its similarity to SMARCE1. Researchers studying HMG20B antibody, HMG20B protein or HMG20B gene questions will often meet these alternative names in the literature, so searching on several of them is worthwhile.
HMG20B is required for correct progression through G2 phase and entry into mitosis, making it relevant to studies of cell division control.
HMG20B is required for RCOR1/CoREST-mediated repression of neuronal-specific gene promoters, so it is relevant to studies of neuronal gene silencing.
As a nuclear, chromosome-associated protein predicted to bind DNA, HMG20B is of interest in studies of gene expression regulation.
HMG20B is predicted to act in positive regulation of neuron differentiation and in skeletal muscle cell differentiation.
HMG20B is required for correct progression through G2 phase of the cell cycle and for entry into mitosis. It is also required for RCOR1/CoREST-mediated repression of neuronal-specific gene promoters. It is a nuclear protein associated with chromosomes.
HMG20B is also called BRAF35, SOXL, HMGX2, SMARCE1r, BRAF25 and HMGXB2. Its earlier HGNC name was high-mobility group 20B. UniProt lists it as SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related.
Yes, the mouse ortholog is Hmg20b, so the gene can be studied in murine systems. HGNC places human HMG20B in the non-canonical high mobility group and among CoREST complex subunits. Check the datasheet of any product for its validated reactivity.
Other high mobility group proteins and chromatin-associated targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9P0W2; product specifications from Assay Genie datasheets.