SCRG1
SCRG1 (stimulator of chondrogenesis 1, also known as scrapie-responsive protein 1 or SCRG-1) is a small secreted protein linked to neurodegenerative changes in prion disease. It also interacts with BST1 in the differentiation of human mesenchymal stem cells. Browse Assay Genie's current range of SCRG1 research reagents below, or read on for the biology behind the target.
SCRG1 is the scrapie-responsive protein 1. According to the NCBI Gene summary, the SCRG1 gene is associated with the neurodegenerative changes seen in transmissible spongiform encephalopathies, and it may contribute to the host response to prion-associated infections. The protein has a hydrophobic N-terminus. For this reason it may be partly inserted into the membrane or secreted by cells, and UniProt lists its subcellular location as secreted.
The encoded protein can interact with bone marrow stromal cell antigen 1 (BST1). This interaction is reported to enhance the differentiation potential of human mesenchymal stem cells, which is relevant to tissue and bone regeneration. Researchers studying stem cell biology and skeletal repair may therefore find SCRG1 a useful protein to measure, alongside BST1.
SCRG1 is the only member named in its family, which UniProt calls the SCRG1 family. The official HGNC name, stimulator of chondrogenesis 1, reflects the link with cartilage and bone formation. The symbol is also written SCRG-1, and lincSCRG1 appears among its aliases. Mouse and rat each have a Scrg1 ortholog, which allows comparative work in common model organisms. Studies of the SCRG1 protein can address both its role in prion-associated neurodegeneration and its role in mesenchymal differentiation.
SCRG1 is associated with neurodegenerative changes in transmissible spongiform encephalopathies and may contribute to host response to prion-associated infections.
SCRG1 can interact with BST1 to enhance the differentiation potential of human mesenchymal stem cells.
The SCRG1–BST1 interaction is linked to differentiation during tissue and bone regeneration, making SCRG1 relevant to regenerative studies.
Its hydrophobic N-terminus suggests membrane association or secretion, which makes SCRG1 a candidate for studying secretion and extracellular localisation.
SCRG1 is associated with neurodegenerative changes in transmissible spongiform encephalopathies and may play a role in host response to prion-associated infections. It can also interact with BST1 to enhance the differentiation potential of human mesenchymal stem cells during tissue and bone regeneration.
SCRG1 stands for stimulator of chondrogenesis 1 (HGNC) and is also called scrapie-responsive protein 1 or scrapie-responsive gene 1. Aliases include SCRG-1 and lincSCRG1. These names refer to the same gene and its 98-amino-acid secreted protein.
Yes. Mouse and rat each have a Scrg1 ortholog of the human SCRG1 gene, so rodent models can be used to study it. Cross-species reactivity differs between reagents, so check the datasheet of any product for its validated reactivity.
BST1, the interaction partner of SCRG1, and other targets in stem cell differentiation and bone regeneration research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75711; product specifications from Assay Genie datasheets.