TAGAP
TAGAP (T cell activation RhoGTPase activating protein) is a member of the Rho GTPase-activator protein superfamily that may act as a GTPase-activating protein during T-cell activation. It is also known as ARHGAP47, IDDM21 and FLJ32631. Browse Assay Genie's current range of TAGAP research reagents below, or read on for the biology behind the target.
TAGAP is annotated as a protein that may function as a GTPase-activating protein, or GAP, and may play important roles during T-cell activation. GAPs act on small GTPases, and the TAGAP protein is assigned to the Rho GTPase-activating protein group, so it is expected to regulate members of the Rho family. The evidence is described cautiously in the databases: the function is predicted rather than fully established, and researchers studying TAGAP typically work from that starting point.
The TAGAP gene encodes a member of the Rho GTPase-activator protein superfamily. HGNC classifies it in the gene group Rho GTPase activating proteins, and the human protein is listed in UniProt as T-cell activation Rho GTPase-activating protein. Alternate splicing of the TAGAP gene produces multiple transcript variants that encode distinct isoforms, which is worth bearing in mind when choosing reagents and interpreting results. The mouse ortholog is Tagap, which allows comparative work in murine systems. No catalytic enzyme classification is assigned to the protein, and a subcellular location is not annotated in UniProt.
The gene has carried several names. Earlier HGNC names were T-cell activation GTPase activating protein and T-cell activation RhoGTPase activating protein, and the current approved symbol is TAGAP. Aliases include ARHGAP47, IDDM21 and FLJ32631. According to the NCBI Gene summary, alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease and multiple sclerosis. These associations are described as possible, so TAGAP is of interest to researchers investigating immune regulation and autoimmune and inflammatory conditions, where it can be studied alongside other Rho signalling components.
TAGAP may play important roles during T-cell activation, making it a candidate regulator to examine in studies of how T cells respond to stimulation.
As a member of the Rho GTPase-activator protein superfamily that may act as a GAP, TAGAP is relevant to studies of Rho family regulation.
Alterations in the TAGAP gene may be associated with rheumatoid arthritis, celiac disease and multiple sclerosis, which motivates its study in autoimmunity.
Alternate splicing yields multiple transcript variants encoding distinct isoforms, so TAGAP is a useful subject for work on transcript diversity.
UniProt states that TAGAP may function as a GTPase-activating protein and may play important roles during T-cell activation. NCBI Gene likewise says the encoded protein may function as a Rho GTPase-activating protein. The activity is therefore predicted, and the details of its targets remain to be established.
TAGAP is also known as ARHGAP47, IDDM21 and FLJ32631. Previous HGNC names were T-cell activation GTPase activating protein and T-cell activation RhoGTPase activating protein. Alternate splicing gives multiple transcript variants that encode distinct isoforms.
NCBI Gene reports that alterations in TAGAP may be associated with rheumatoid arthritis, celiac disease and multiple sclerosis. The mouse ortholog is Tagap. Cross-reactivity cannot be assumed, so check the datasheet of any product for its validated reactivity.
Other Rho GTPase-activating proteins, Rho family GTPases and T-cell activation markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N103; product specifications from Assay Genie datasheets.