FGF22
FGF22 (fibroblast growth factor 22) is a secreted, heparin-binding member of the fibroblast growth factor family. It has been linked to the fasting response, glucose homeostasis, lipolysis and lipogenesis, and may contribute to hair development. Browse Assay Genie's current range of FGF22 research reagents below, or read on for the biology behind the target.
FGF22 is a secreted signalling protein that belongs to the heparin-binding growth factors family. UniProt annotates a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. In vitro, FGF22 can stimulate cell proliferation, and it may be involved in hair development.
The FGF22 gene encodes a member of the fibroblast growth factor (FGF) family, which is classed by HGNC in the fibroblast growth factor family gene group. FGF family members possess broad mitogenic and cell survival activities. They take part in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumour growth and invasion. The FGF22 protein is secreted, consistent with its function as an extracellular signalling factor. Alternative splicing of the gene results in multiple transcript variants.
The suggested link to hair biology comes from work on the mouse homologue, Fgf22, which was found to be preferentially expressed in the inner root sheath of the hair follicle. This pointed to a role in hair development. Researchers studying FGF22 often consider it alongside other FGF family members, as well as the metabolic roles annotated for it, such as lipid handling and glucose homeostasis.
FGF22 is annotated with roles in the fasting response, glucose homeostasis, lipolysis and lipogenesis, making it relevant to studies of energy metabolism.
Mouse Fgf22 is preferentially expressed in the inner root sheath of the hair follicle, suggesting a role in hair development.
FGF22 can stimulate cell proliferation in vitro, and FGF family members have broad mitogenic and cell survival activities.
FGF family members are involved in embryonic development, morphogenesis and tissue repair, placing FGF22 within wider growth factor research.
FGF22 is a secreted fibroblast growth factor that plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. It can stimulate cell proliferation in vitro and may be involved in hair development, according to UniProt annotation.
The approved HGNC name is fibroblast growth factor 22, and no alternative aliases or previous symbols are listed. NCBI Gene reports that alternative splicing of the FGF22 gene results in multiple transcript variants.
A mouse ortholog, Fgf22, exists. It was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Check the datasheet of any product for its validated reactivity.
Other fibroblast growth factors, FGF-binding proteins and FGF receptors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9HCT0; product specifications from Assay Genie datasheets.