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FAR2
FAR2 (fatty acyl-CoA reductase 2) is a peroxisomal membrane enzyme that reduces saturated C16 and C18 fatty acyl-CoA to fatty alcohols. It is also known as SDR10E2, MLSTD1 and FLJ10462, and belongs to the short chain dehydrogenase/reductase superfamily. Browse Assay Genie's current range of FAR2 research reagents below, or read on for the biology behind the target.
FAR2 catalyses the reduction of saturated, but not unsaturated, C16 or C18 fatty acyl-CoA to fatty alcohols. Shorter fatty acyl-CoA substrates are used with lower activity. The enzyme can produce very long-chain and ultra long-chain fatty alcohols, whether the chain is straight or branched. This reaction is the first step of wax biosynthesis, in which fatty acids are converted to fatty alcohols.
Fatty alcohols are required substrates for the synthesis of ether lipids, including plasmalogens, and of wax monoesters, so FAR2 is involved in the production of these lipid classes. The protein is assigned to the fatty acyl-CoA reductase family and is located at the peroxisome membrane. Studies of FAR2 protein levels, localisation and activity are relevant to peroxisomal lipid metabolism.
The FAR2 gene belongs to the short chain dehydrogenase/reductase superfamily, and its enzyme activity is classified as EC 1.2.1.84. Alternatively spliced transcript variants have been observed, and related pseudogenes are found on chromosomes 2, 14 and 22. The gene was previously named male sterility domain containing 1 (MLSTD1), and the mouse ortholog is Far2.
FAR2 carries out the first step of wax biosynthesis, converting fatty acids to fatty alcohols.
Ether lipids and plasmalogens require fatty alcohols as substrates, linking FAR2 to their production.
As a peroxisome membrane enzyme, FAR2 is a useful target for studying fatty acyl-CoA handling in this organelle.
FAR2 prefers saturated C16 and C18 substrates and can generate very long-chain and branched fatty alcohols.
FAR2 reduces saturated C16 and C18 fatty acyl-CoA to fatty alcohols, with lower activity on shorter substrates. These fatty alcohols are needed for wax monoesters and for ether lipids such as plasmalogens. The enzyme sits in the peroxisome membrane.
FAR2 stands for fatty acyl-CoA reductase 2. Aliases and previous symbols include SDR10E2, MLSTD1 and FLJ10462, and the earlier gene name was male sterility domain containing 1. Alternatively spliced transcript variants have been reported for the gene.
A mouse ortholog, Far2, is recorded for the human gene. The human gene also has related pseudogenes on chromosomes 2, 14 and 22. Check the datasheet of any product for its validated reactivity.
Other fatty acid metabolism enzymes and members of the short chain dehydrogenase/reductase superfamily may also be of interest.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96K12; product specifications from Assay Genie datasheets.
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