NEUROD1
NEUROD1 (neuronal differentiation 1, also known as NeuroD, BETA2, BHF-1, bHLHa3 and MODY6) is a basic helix-loop-helix transcription factor that activates genes carrying E-box sequences. It contributes to neuronal and endocrine cell differentiation and regulates insulin gene expression. Browse Assay Genie's current range of NEUROD1 research reagents below, or read on for the biology behind the target.
NEUROD1 acts as a transcriptional activator. It binds E box-containing promoter consensus core sequences, 5'-CANNTG-3', and associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene and of the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. It also associates with chromatin at enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis.
The protein contributes to several cell differentiation pathways. These include the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells of the cerebellum or the dentate gyrus of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, NEUROD1 is required for amacrine cell fate specification, and it is also required for dendrite morphogenesis and maintenance in the cerebellar cortex. UniProt lists its subcellular location as the cytoplasm and the nucleus.
The NEUROD1 gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors, which form heterodimers with other bHLH proteins. HGNC places it in the basic helix-loop-helix protein group and records the previous name neurogenic differentiation 1. NEUROD1 regulates expression of the insulin gene, and mutations in the gene result in type II diabetes mellitus. The MODY6 alias reflects this link to diabetes. Mouse and rat orthologs are both named Neurod1, so the factor is studied in rodent models of development and islet biology.
NEUROD1 binds enhancers of key neurogenic transcriptional regulators and supports differentiation of retinal, inner ear, cerebellar and hippocampal neurons.
The factor helps drive endocrine islet cell formation and regulates the insulin gene, making it a focus for beta cell studies.
Mutations in the NEUROD1 gene result in type II diabetes mellitus, and the MODY6 alias reflects this disease association.
NEUROD1 binds E-box sequences and recruits the p300/CBP coactivator complex to activate targets such as secretin and CDKN1A.
NEUROD1 is a transcriptional activator that binds E-box sequences (5'-CANNTG-3') and works with the p300/CBP coactivator complex. It contributes to differentiation of neurons, pancreatic islet cells and enteroendocrine cells, and it regulates expression of the insulin gene.
NEUROD1 is also called NeuroD, NEUROD, BETA2, BHF-1, bHLHa3 and MODY6. UniProt names the protein neurogenic differentiation factor 1, and HGNC records the earlier name neurogenic differentiation 1 alongside the current name neuronal differentiation 1.
NCBI Gene reports that mutations in NEUROD1 result in type II diabetes mellitus, consistent with the MODY6 alias. Orthologs named Neurod1 exist in mouse and rat. Check the datasheet of any product for its validated reactivity.
Other NeuroD family bHLH transcription factors involved in neuronal differentiation.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13562; product specifications from Assay Genie datasheets.