CYTL1
CYTL1 (cytokine like 1) is a secreted cytokine-like protein, also known as C17 and previously designated C4orf4. It is specifically expressed in bone marrow and cord blood mononuclear cells that carry the CD34 surface marker. Browse Assay Genie's current range of CYTL1 research reagents below, or read on for the biology behind the target.
CYTL1, the protein product of the cytokine like 1 gene, is a secreted protein classified as cytokine-like. The name reflects its resemblance to cytokines, although the source annotation available for this entry does not describe a defined receptor, signalling mechanism or catalytic activity, so these are not discussed here.
The best-characterised feature of the CYTL1 gene is its restricted expression pattern. According to the NCBI Gene summary, which cites Liu et al. (2000), the protein, referred to there as C17, is specifically expressed in bone marrow and in cord blood mononuclear cells that bear the CD34 surface marker. CD34 is widely used as a marker of primitive haematopoietic cells, which places CYTL1 in the context of blood cell biology and makes it a point of interest for researchers working on these populations.
The protein is listed in UniProt as cytokine-like protein 1 and is annotated as secreted. HGNC records the approved name as cytokine like 1, with the previous name cytokine-like 1. Earlier literature and databases may use the alias C17 or the previous symbol C4orf4, so searches covering all three names help when reviewing publications. Researchers studying CYTL1 will commonly work with a CYTL1 antibody or a CYTL1 ELISA kit, or with recombinant CYTL1 protein, to examine where and when it is produced.
CYTL1 is expressed in CD34-bearing mononuclear cells of bone marrow and cord blood, making it relevant to studies of these cell populations.
As a secreted cytokine-like protein identified by expression profiling, CYTL1 is a candidate for work on previously uncharacterised extracellular signalling molecules.
Its specific expression in bone marrow and cord blood mononuclear cells makes CYTL1 a useful target for tissue- and cell-restricted expression analysis.
CYTL1 is annotated as a secreted protein, so it is relevant to studies of extracellular factors released by blood-forming cell populations.
The available source text does not define a detailed molecular function. CYTL1 is described as a secreted, cytokine-like protein that is specifically expressed in bone marrow and cord blood mononuclear cells bearing the CD34 surface marker, which points to a role in haematopoietic cell biology.
CYTL1 stands for cytokine like 1, and UniProt lists the protein as cytokine-like protein 1. It is also known as C17, and its previous gene symbol was C4orf4. The previous HGNC name was cytokine-like 1. Use all of these terms when searching the literature.
The data supplied for this page do not list mouse or rat orthologs, so conservation is not described here. Researchers working in non-human models should consult ortholog databases and check the datasheet of any product for its validated reactivity.
Other cytokines and haematopoietic markers, such as CD34, with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NRR1; product specifications from Assay Genie datasheets.