CCDC6
CCDC6 (coiled-coil domain containing 6) is a cytoplasmic coiled-coil protein that acts as a structural scaffold for the phosphatase PP2Ac and may function as a tumour suppressor. It is also known as PTC, TPC, H4, PTC1, TST1 and D10S170. Browse Assay Genie's current range of CCDC6 research reagents below, or read on for the biology behind the target.
CCDC6 acts as a structural scaffold. It organises free PP2Ac into a configuration that the F-box protein FBXO42 can recognise and ubiquitinate, which leads to proteasomal degradation of PP2Ac. CCDC6 also interacts with PPP4C independently, through a mechanism distinct from FBXO42-mediated ubiquitination.
The CCDC6 gene encodes a coiled-coil domain-containing protein that is ubiquitously expressed. In UniProt the protein is annotated as localising to the cytoplasm and the cytoskeleton. NCBI Gene notes that the encoded protein may function as a tumour suppressor, so the CCDC6 protein is often studied in the context of cell growth control and cancer biology. A mouse ortholog, Ccdc6, is recorded for the gene.
The many aliases for CCDC6 reflect its history. Earlier names include transforming sequence, thyroid-1 (TST1) and DNA segment on chromosome 10 (unique) 170 (D10S170), while the symbols PTC, TPC, H4 and PTC1 relate to thyroid papillary carcinoma. A chromosomal rearrangement joins a portion of the CCDC6 gene to the intracellular kinase-encoding domain of the ret proto-oncogene. The resulting fusion gene is the cause of thyroid papillary carcinoma, which makes CCDC6 a well-known example of a gene involved in an oncogenic rearrangement.
A rearrangement fusing CCDC6 to the kinase-encoding domain of RET causes thyroid papillary carcinoma, making the gene central to studies of this fusion.
CCDC6 may function as a tumour suppressor, so its expression and loss are of interest in cancer biology.
CCDC6 scaffolds free PP2Ac for FBXO42-mediated ubiquitination and interacts with PPP4C, linking it to phosphatase control.
By presenting PP2Ac to FBXO42, CCDC6 contributes to ubiquitination and proteasomal degradation, a useful model of scaffold-assisted substrate recognition.
CCDC6 acts as a structural scaffold that organises free PP2Ac into a form FBXO42 can recognise and ubiquitinate, leading to proteasomal degradation. It also interacts with PPP4C by a separate mechanism. NCBI Gene notes it may function as a tumour suppressor.
CCDC6 is also called PTC, TPC, H4, PTC1, TST1 and D10S170. Previous names include transforming sequence, thyroid-1 and DNA segment on chromosome 10 (unique) 170. The thyroid-related names stem from its involvement in a RET rearrangement.
A chromosomal rearrangement produces a fusion gene combining part of CCDC6 with the intracellular kinase-encoding domain of the ret proto-oncogene. This fusion causes thyroid papillary carcinoma. A mouse ortholog, Ccdc6, exists; check the datasheet of any product for its validated reactivity.
Other coiled-coil domain-containing proteins with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16204; product specifications from Assay Genie datasheets.