ADCK2
ADCK2 (aarF domain containing kinase 2, also known as MGC20727) is a mitochondrial member of the ADCK protein kinase family. It has been linked to the import of coenzyme Q precursors, muscle mitochondrial function and fatty acid beta-oxidation. Browse Assay Genie's current range of ADCK2 research reagents below, or read on for the biology behind the target.
ADCK2 is annotated as an uncharacterised aarF domain-containing protein kinase, and its biochemical function is not yet clear. It is not known whether it has protein kinase activity, or which residue type (serine, threonine or tyrosine) it would phosphorylate. Genome annotation predicts ATP binding and protein serine/threonine kinase activity, but this remains a prediction. Reported roles centre on mitochondria: ADCK2 is involved in the mitochondrial import of coenzyme Q (CoQ) precursors, and it plays a role in muscle mitochondrial function and fatty acid beta-oxidation.
The ADCK2 gene encodes a protein that belongs to the protein kinase superfamily and the ADCK protein kinase family, which HGNC groups as the ADCK family. UniProt lists its subcellular location as mitochondrion and membrane, in agreement with the NCBI Gene summary, which places it in the mitochondrion. The enzyme classification is EC 2.7.11.-, the general class for serine/threonine protein kinases. The mouse ortholog is Adck2.
Annotation links ADCK2 to the regulation of the ubiquinone biosynthetic process, the pathway that produces CoQ. Ubiquinone is the same molecule as CoQ, so this fits with the reported role in importing CoQ precursors into mitochondria. Because the catalytic activity is unconfirmed, researchers studying the ADCK2 protein usually look at its mitochondrial localisation and its relationship to other ADCK family members, such as ADCK1 and ADCK5.
ADCK2 is involved in the mitochondrial import of CoQ precursors and in regulating the ubiquinone biosynthetic process.
ADCK2 plays a role in muscle mitochondrial function, making it a candidate for studies of mitochondrial performance in muscle.
ADCK2 has been implicated in fatty acid beta-oxidation, a mitochondrial pathway central to cellular energy metabolism.
Whether ADCK2 has protein kinase activity is unresolved, so it is relevant to work on the ADCK family and the protein kinase superfamily.
ADCK2 is involved in the mitochondrial import of coenzyme Q precursors and plays a role in muscle mitochondrial function and fatty acid beta-oxidation. Its exact molecular function is not yet clear, and it is not known whether it has protein kinase activity.
The HGNC name is aarF domain containing kinase 2, and MGC20727 is a listed alias. UniProt names the protein uncharacterized aarF domain-containing protein kinase 2. It belongs to the ADCK family, and the gene is annotated with the enzyme class EC 2.7.11.-.
A mouse ortholog, Adck2, is recorded for the human gene. ADCK2 is also a member of the ADCK protein kinase family within the protein kinase superfamily. Check the datasheet of any product for its validated reactivity.
Other ADCK family kinases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q7Z695; product specifications from Assay Genie datasheets.