SGPP2
SGPP2 (sphingosine-1-phosphate phosphatase 2, also known as SPP2 or FLJ39004) is an endoplasmic reticulum membrane enzyme that removes the phosphate group from sphingoid base 1-phosphates. By degrading sphingosine 1-phosphate (S1P), it links sphingolipid recycling to cell signalling. Browse Assay Genie's current range of SGPP2 research reagents below, or read on for the biology behind the target.
SGPP2 is a phosphohydrolase with specific activity towards sphingoid base 1-phosphates. In vitro it shows high activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P). This activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway. Because it degrades S1P, a bioactive signalling molecule, SGPP2 may also help attenuate intracellular S1P signalling.
The SGPP2 gene encodes a transmembrane protein that localises to the endoplasmic reticulum membrane. It belongs to the type 2 lipid phosphate phosphatase family and is classed by HGNC in the sphingosine-1-phosphate phosphatases gene group, alongside SGPP1. Alternative splice variants encoding different isoforms have been reported for the gene. The mouse ortholog is Sgpp2.
Beyond lipid recycling, SGPP2 has been linked to inflammation and cell stress. The protein is induced during inflammatory responses, and UniProt notes that it may play a role in pro-inflammatory signalling. It also contributes to the regulation of endoplasmic reticulum stress and proliferation in pancreatic islet beta cells. NCBI Gene reports that SGPP2 expression is downregulated by the microRNA-31 tumour suppressor. These features make the SGPP2 protein a useful subject for studies of sphingolipid metabolism, inflammatory signalling and beta-cell biology.
SGPP2 dephosphorylates sphingoid base 1-phosphates, supporting the recycling of sphingosine into the sphingolipid synthesis pathway.
By degrading sphingosine 1-phosphate, SGPP2 may attenuate intracellular S1P signalling, making it relevant to studies of this bioactive lipid.
SGPP2 is induced during inflammatory responses and may contribute to pro-inflammatory signalling.
SGPP2 helps regulate endoplasmic reticulum stress and proliferation in pancreatic islet beta cells.
SGPP2 is a phosphohydrolase that acts on sphingoid base 1-phosphates, including sphingosine-1-phosphate and dihydrosphingosine-1-phosphate. Its activity supports recycling of sphingosine into sphingolipid synthesis and may attenuate intracellular S1P signalling. It also contributes to regulating endoplasmic reticulum stress and proliferation in pancreatic islet beta cells.
SGPP2 is the HGNC symbol for sphingosine-1-phosphate phosphatase 2. It is also known as SPP2 and FLJ39004. NCBI Gene notes that alternative splice variants encoding different isoforms have been found, so check which isoform a reagent recognises.
NCBI Gene reports that SGPP2 is induced during inflammatory responses, and UniProt suggests a role in pro-inflammatory signalling. It is also downregulated by microRNA-31. A mouse ortholog, Sgpp2, exists; check the datasheet of any product for its validated reactivity.
The related sphingosine-1-phosphate phosphatase SGPP1 and other sphingolipid-pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8IWX5; product specifications from Assay Genie datasheets.