EphA2
EphA2 (EPH receptor A2, also known as ECK) is a receptor tyrosine kinase of the ephrin receptor subfamily that binds ephrin-A ligands. It has been linked to developmental events, particularly in the nervous system, and acts as a receptor for human cytomegalovirus in glioblastoma cells. Browse Assay Genie's current range of EphA2 research reagents below, or read on for the biology behind the target.
EphA2 is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family, and belongs to the wider protein kinase superfamily. As a receptor tyrosine kinase (EC 2.7.10.1), it binds ephrin-A ligands. The EphA2 protein also serves as a receptor for human cytomegalovirus (HCMV), mediating viral entry and fusion in glioblastoma cells.
Ephrin receptors are divided into two groups according to the similarity of their extracellular domain sequences and their affinities for ephrin-A and ephrin-B ligands. EphA2 falls in the group that binds ephrin-A ligands. Receptors of the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and two fibronectin type III repeats. In UniProt, EphA2 is annotated at the cell membrane, including ruffle membrane, lamellipodium membrane and focal adhesions.
The EPHA2 gene is placed by HGNC in the EPH receptor group and in the sterile alpha motif domain containing group. The symbol ECK is a recorded alias, and EphA2 is a previous name. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Mutations in the EphA2 gene are the cause of certain genetically related cataract disorders. A mouse ortholog, Epha2, is recorded for comparative work.
EphA2 binds ephrin-A ligands, making it a representative receptor for studying how the EPH family mediates cell-surface signalling.
EPH and EPH-related receptors have been implicated in developmental events, particularly in the nervous system.
EphA2 acts as a receptor for human cytomegalovirus, mediating viral entry and fusion in glioblastoma cells.
Mutations in the EPHA2 gene cause certain genetically related cataract disorders, so the protein is relevant to inherited eye disease.
EphA2 is a receptor tyrosine kinase that binds ephrin-A ligands. EPH receptors are implicated in developmental events, particularly in the nervous system. EphA2 also acts as a receptor for human cytomegalovirus, mediating viral entry and fusion in glioblastoma cells.
The HGNC name is EPH receptor A2 and the UniProt name is ephrin type-A receptor 2. ECK is a recorded alias, and EphA2 is listed as a previous name. The gene symbol is EPHA2, and the protein is classed as EC 2.7.10.1.
Mutations in the EphA2 gene are the cause of certain genetically related cataract disorders. The protein is also an HCMV receptor in glioblastoma cells. A mouse ortholog, Epha2, exists; check the datasheet of any product for its validated reactivity.
Other EPH receptor A family members and related ephrin receptor tyrosine kinases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P29317; product specifications from Assay Genie datasheets.