DOK6
DOK6 (docking protein 6, also known as DOK5L, MGC20785 and HsT3226) is an enzymatically inert adaptor protein of the DOK family. It provides a docking platform for multimolecular signalling complexes and promotes Ret-mediated neurite growth. Browse Assay Genie's current range of DOK6 research reagents below, or read on for the biology behind the target.
DOK6 is an adaptor, or scaffolding, protein. Like other DOK proteins it is enzymatically inert: rather than catalysing a reaction, it provides a docking platform on which multimolecular signalling complexes are assembled. The best-characterised role of DOK6 is in the RET signalling cascade, where it promotes Ret-mediated neurite growth. It may also have a role in brain development and/or maintenance.
The DOK6 gene encodes docking protein 6, which belongs to the DOK family and, within it, the type B subfamily. HGNC places it in the pleckstrin homology domain containing group as well as the docking protein family. The NCBI Gene summary describes DOK6 as a member of the DOK family of intracellular adaptors, alongside DOK1, that play a role in the RET signalling cascade. A mouse ortholog, Dok6, is recognised.
The protein was previously named docking protein 5-like, and the symbol DOK5L, along with MGC20785 and HsT3226, still appears in older literature and database records. Researchers studying DOK6 will often compare it with other DOK family members such as DOK1, DOK2, DOK3 and DOK7 when examining adaptor function in receptor tyrosine kinase signalling and neuronal development.
DOK6 promotes Ret-mediated neurite growth, making it a relevant target for studies of how neurites extend downstream of RET.
DOK6 is an intracellular adaptor in the RET signalling cascade, so it is studied to understand how adaptor proteins shape RET output.
DOK6 may have a role in brain development and/or maintenance, which motivates its investigation in neural biology.
As an enzymatically inert docking protein, DOK6 helps address how scaffolds assemble multimolecular signalling complexes.
DOK6 is an enzymatically inert adaptor protein that provides a docking platform for assembling multimolecular signalling complexes. It promotes Ret-mediated neurite growth and may have a role in brain development and/or maintenance. It acts within the RET signalling cascade.
DOK6 stands for docking protein 6. Its previous name was docking protein 5-like, and the earlier symbol is DOK5L. Other aliases found in databases include MGC20785 and HsT3226. These names refer to the same gene and protein, so all are worth searching.
DOK6 belongs to the DOK family of intracellular adaptors, in the type B subfamily, and is grouped with pleckstrin homology domain containing proteins. DOK1 is the family member cited in its gene summary. A mouse ortholog, Dok6, exists; check the datasheet of any product for its validated reactivity.
Other DOK family adaptor proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6PKX4; product specifications from Assay Genie datasheets.