SLC16A14

SLC16A14

Target · Monocarboxylate transporter

SLC16A14 Solute carrier family 16 member 14 · Monocarboxylate transporter 14

SLC16A14, also known as monocarboxylate transporter 14 (MCT14) or FLJ30794, is a proton-linked monocarboxylate transporter of the solute carrier family 16. It is thought to catalyse the movement of monocarboxylates across the plasma membrane. Browse Assay Genie's current range of SLC16A14 research reagents below, or read on for the biology behind the target.

Cell membrane proteinProton-linked transporterMajor facilitator superfamily
510 aa
Protein length
~56 kDa
Molecular weight
2q36.3
Gene locus
MFS transporter
Protein family
Target information

What is SLC16A14 (solute carrier family 16 member 14)?

SLC16A14 is annotated as a proton-linked monocarboxylate transporter. According to UniProt, it may catalyse the transport of monocarboxylates across the plasma membrane. The NCBI Gene summary is consistent with this: the gene is predicted to enable monocarboxylic acid transmembrane transporter activity and to be involved in carboxylic acid transmembrane transport. These assignments are predictions, so the precise substrates and transport mechanism of monocarboxylate transporter 14 remain to be established experimentally.

The SLC16A14 protein belongs to the major facilitator superfamily and to the monocarboxylate porter family (TC 2.A.1.13). It is localised to the cell membrane, and the NCBI Gene summary predicts it to be active in the plasma membrane. In HGNC the gene sits in the solute carrier family 16 group, which also includes better-characterised monocarboxylate transporters such as SLC16A1, SLC16A3 and SLC16A7. The mouse ortholog is Slc16a14.

The approved name is solute carrier family 16 member 14. Earlier names were solute carrier family 16 (monocarboxylic acid transporters), member 14, and the gene has also been referred to as MCT14 and FLJ30794. Researchers studying the SLC16A14 gene or its product will often compare it with other SLC16 family members to place it within the wider network of membrane transporters that move small organic acids across cellular membranes.

Membrane transport biology

SLC16A14 is a predicted plasma membrane transporter of monocarboxylates, making it a candidate for studies of carboxylic acid transmembrane transport.

Solute carrier family comparisons

As a member of solute carrier family 16, it is studied alongside other monocarboxylate transporters to compare family relationships and function.

Proton-coupled transport

UniProt describes it as proton-linked, so it is relevant to work on how proton gradients drive monocarboxylate movement across membranes.

Orphan transporter characterisation

Its function is largely predicted, so defining substrates and activity remains an open question in transporter research.

Background

SLC16A14 frequently asked questions

What does SLC16A14 do?

SLC16A14 is annotated as a proton-linked monocarboxylate transporter that may catalyse the transport of monocarboxylates across the plasma membrane. NCBI Gene also predicts monocarboxylic acid transmembrane transporter activity, though its exact substrates are not established in the sources.

What other names does SLC16A14 go by?

The approved name is solute carrier family 16 member 14. UniProt calls the protein monocarboxylate transporter 14, and aliases include MCT14 and FLJ30794. Older names described it as solute carrier family 16 (monocarboxylic acid transporters), member 14.

Is SLC16A14 conserved across species?

A mouse ortholog, Slc16a14, is recorded for the human gene. The protein belongs to the monocarboxylate porter family within the major facilitator superfamily. Check the datasheet of any product for its validated reactivity.

Explore

Related targets

Other solute carrier family 16 monocarboxylate transporters and neighbouring SLC transporters with products at Assay Genie.

Gene and protein annotations from HGNC, NCBI Gene and UniProt Q7RTX9; product specifications from Assay Genie datasheets.

SLC16A14 Product listing

There are no products listed under this category.