CD99
CD99 is a cell surface glycoprotein of the CD99 family that contributes to T-cell adhesion and leukocyte migration. It is also known as MIC2, MIC2X or MIC2Y, and its gene lies in the pseudoautosomal region shared by the X and Y chromosomes. Browse Assay Genie's current range of CD99 research reagents below, or read on for the biology behind the target.
CD99 is a membrane glycoprotein involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. It also plays a role in a late step of leukocyte extravasation, helping leukocytes to overcome the endothelial basement membrane. In this process CD99 acts at the same site as PECAM1 but independently of it. The NCBI Gene summary additionally links the protein to ganglioside GM1 and transmembrane protein transport, and to T-cell death through a caspase-independent pathway.
The CD99 gene encodes a cell surface glycoprotein that belongs to the CD99 family. The protein may rearrange the actin cytoskeleton and may act as an oncosuppressor in osteosarcoma. The CD99 gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. A related pseudogene sits immediately adjacent to this locus. The mouse ortholog is Cd99.
The gene symbol and name reflect its history. HGNC lists CD99 under blood group antigens, CD molecules and pseudoautosomal region 1. Previous names include antigen identified by monoclonal antibodies 12E7, F21 and O13, and the aliases MIC2, MIC2X and MIC2Y are still found in older literature. Researchers studying leukocyte trafficking, T-cell biology or osteosarcoma will often meet CD99 in these contexts, so it is useful to recognise both the current and the historical nomenclature when searching the literature or choosing a CD99 antibody or CD99 ELISA kit.
CD99 acts in a late step of extravasation, helping leukocytes cross the endothelial basement membrane independently of PECAM1.
CD99 is involved in T-cell adhesion processes and in rosette formation with erythrocytes, making it relevant to cell-contact studies.
CD99 may act as an oncosuppressor in osteosarcoma, which makes it a point of interest in tumour biology.
CD99 may rearrange the actin cytoskeleton and has been linked to caspase-independent T-cell death.
CD99 is a cell surface glycoprotein involved in T-cell adhesion and in spontaneous rosette formation with erythrocytes. It acts in a late step of leukocyte extravasation, helping leukocytes pass the endothelial basement membrane, at the same site as PECAM1 but independently of it.
CD99 is also called MIC2, MIC2X and MIC2Y. HGNC lists the full name as CD99 molecule (Xg blood group), and earlier names include antigen identified by monoclonal antibodies 12E7, F21 and O13. UniProt names the protein CD99 antigen.
A mouse ortholog, Cd99, is recorded. The human CD99 gene lies in the pseudoautosomal region of the X and Y chromosomes and escapes X-chromosome inactivation. A related pseudogene sits immediately next to it. Check the datasheet of any product for its validated reactivity.
Other CD molecules, leukocyte adhesion and migration markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P14209; product specifications from Assay Genie datasheets.