GIPR
GIPR (gastric inhibitory polypeptide receptor) is a cell-membrane G protein-coupled receptor for GIP. Its activity is mediated by G proteins that activate adenylyl cyclase, linking GIP binding to insulin-related signalling. Browse Assay Genie's current range of GIPR research reagents below, or read on for the biology behind the target.
GIPR is the receptor for GIP, gastric inhibitory polypeptide. It sits in the cell membrane and signals through G proteins, which activate adenylyl cyclase. This coupling turns extracellular GIP binding into an intracellular response, so the receptor is a central point for studying how GIP acts on target cells.
The GIPR gene encodes a protein that belongs to the G protein-coupled receptor 2 family. HGNC places it in the glucagon receptor family. It is also listed among the microRNA protein coding host genes. Researchers working on the GIPR protein often study it alongside other family 2 receptors that respond to peptide hormones.
GIP was first identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, which gave rise to the name gastric inhibitory polypeptide. It was later shown to stimulate insulin release in the presence of elevated glucose. GIPR mediates this role. Mice lacking the gene, Gipr in mouse and rat, show higher blood glucose levels and an impaired initial insulin response after an oral glucose load. For this reason, defects in the GIPR gene may contribute to the pathogenesis of diabetes. Studies of the receptor therefore span gut hormone biology, glucose homeostasis and metabolic disease, and GIPR antibody and GIPR ELISA kit approaches are common tools in this work.
Defects in the GIPR gene may contribute to the pathogenesis of diabetes, making the receptor relevant to studies of impaired glucose handling.
GIP stimulates insulin release when glucose is elevated, and GIPR mediates this response in the presence of high glucose.
GIPR couples to G proteins that activate adenylyl cyclase, offering a model for family 2 receptor signalling.
GIP was first found in gut extracts that inhibited gastric acid secretion and gastrin release, so its receptor links gut and metabolism.
GIPR is the receptor for GIP. When GIP binds, G proteins activate adenylyl cyclase. GIP stimulates insulin release in the presence of elevated glucose, and GIPR mediates this response. Check the datasheet of any product for its validated reactivity.
The approved name is gastric inhibitory polypeptide receptor, and no other aliases or previous symbols are listed. It belongs to the G protein-coupled receptor 2 family, and HGNC places it in the glucagon receptor family of genes.
Mouse and rat both have a Gipr ortholog. Mice lacking the gene show higher blood glucose and an impaired initial insulin response after oral glucose, so defects in this gene may contribute to the pathogenesis of diabetes.
Other glucagon receptor family members, GIP ligand and insulin-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P48546; product specifications from Assay Genie datasheets.