ALDH16A1
ALDH16A1 (aldehyde dehydrogenase 16 family member A1, previously MGC10204) is a member of the aldehyde dehydrogenase superfamily. The encoded protein is reported to interact with maspardin, a protein linked to Mast syndrome when truncated. Browse Assay Genie's current range of ALDH16A1 research reagents below, or read on for the biology behind the target.
ALDH16A1 belongs to the aldehyde dehydrogenase superfamily. According to the NCBI Gene summary, members of this family act on aldehyde substrates and use nicotinamide adenine dinucleotide phosphate (NADP) as a cofactor. UniProt places the ALDH16A1 protein in the aldehyde dehydrogenase family, although no specific function annotation or subcellular location is currently recorded for it.
The ALDH16A1 gene is listed by HGNC within the aldehyde dehydrogenases gene group under the name aldehyde dehydrogenase 16 family member A1. The older symbol MGC10204 and the earlier name 'aldehyde dehydrogenase 16 family, member A1' may still appear in the literature and in database records. The gene is conserved in chimpanzee, dog, cow, mouse, rat and zebrafish, and mouse and rat orthologs are both named Aldh16a1, which supports comparative work in common model organisms.
A notable feature reported for the ALDH16A1 protein is its interaction with maspardin. Truncation of maspardin is responsible for Mast syndrome, so this interaction is the main disease-relevant link described in the gene summary. Alternatively spliced transcript variants encoding different isoforms have also been found, which is worth bearing in mind when designing experiments against ALDH16A1 transcripts or protein, whether using an ALDH16A1 antibody or an ALDH16A1 ELISA kit.
ALDH16A1 is part of the aldehyde dehydrogenase superfamily, whose members act on aldehyde substrates with NADP as cofactor, making it relevant to comparative family studies.
The reported interaction between ALDH16A1 and maspardin provides a starting point for work on protein partners linked to Mast syndrome.
Alternatively spliced transcripts encode different ALDH16A1 isoforms, so the gene is relevant to studies of transcript diversity and isoform-specific expression.
Conservation of the gene in chimpanzee, dog, cow, mouse, rat and zebrafish supports cross-species investigation of ALDH16A1 function.
ALDH16A1 is a member of the aldehyde dehydrogenase superfamily, a group of proteins that act on aldehyde substrates and use NADP as a cofactor. No specific function annotation is currently recorded in UniProt, but the protein is reported to interact with maspardin.
The HGNC name is aldehyde dehydrogenase 16 family member A1, and the previous symbol is MGC10204. The earlier name was 'aldehyde dehydrogenase 16 family, member A1'. Alternatively spliced transcript variants encoding different isoforms have been described for the ALDH16A1 gene.
The gene is conserved in chimpanzee, dog, cow, mouse, rat and zebrafish; mouse and rat orthologs are named Aldh16a1. The protein interacts with maspardin, which causes Mast syndrome when truncated. Check the datasheet of any product for its validated reactivity.
Other members of the aldehyde dehydrogenase family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8IZ83; product specifications from Assay Genie datasheets.