CIC
CIC (capicua transcriptional repressor, also known as KIAA0306) is a nuclear HMG-box transcriptional repressor that contributes to development of the central nervous system. It is the human ortholog of the Drosophila melanogaster capicua gene. Browse Assay Genie's current range of CIC research reagents below, or read on for the biology behind the target.
CIC is a transcriptional repressor that plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, it is involved in brain development. Studies suggest that the N-terminal region of the CIC protein interacts with ATXN1 to form a transcription repressor complex, and in vitro work indicates that polyglutamine expansion of ATXN1 may alter the repressor activity of this complex.
The CIC gene encodes a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. The protein contains a conserved HMG domain, which is involved in DNA binding and nuclear localization, and a conserved C-terminus. Consistent with its role in gene regulation, CIC is found in the nucleus. Alternative splicing of the CIC gene results in multiple transcript variants that encode different isoforms, and multiple pseudogenes are found on chromosomes 1, 4, 6, 7, 16, 20 and the Y chromosome. The mouse ortholog is Cic.
The name reflects its origin as the human counterpart of Drosophila capicua; earlier names include capicua (Drosophila) homolog, and the symbol KIAA0306 is also used. CIC is linked to disease in several ways. Mutations in this gene have been associated with oligodendrogliomas, and translocations that fuse CIC with DUX4 or FOXO4 have been associated with round cell sarcomas. These links make the CIC protein a subject of interest in neurobiology and cancer research.
CIC acts as a transcriptional repressor in central nervous system development and works with ATXN1 and ATXN1L in brain development.
As an HMG-box protein, CIC binds DNA through its HMG domain to repress gene expression, making it a model for repressor complex studies.
CIC interacts with ATXN1, and polyglutamine expansion of ATXN1 may alter the activity of the resulting repressor complex.
CIC mutations are associated with oligodendrogliomas, and CIC fusions with DUX4 or FOXO4 are associated with round cell sarcomas.
CIC is a nuclear transcriptional repressor that plays a role in central nervous system development. Together with ATXN1 and ATXN1L it is involved in brain development. Its N-terminal region is reported to interact with ATXN1 to form a transcription repressor complex.
CIC is also known as KIAA0306, and earlier names were capicua (Drosophila) homolog and capicua homolog (Drosophila). UniProt calls it Protein capicua homolog. Alternative splicing of the gene produces multiple transcript variants that encode different isoforms.
CIC is the ortholog of Drosophila capicua, and the mouse counterpart is Cic. Mutations in the gene have been associated with oligodendrogliomas, and fusions with DUX4 or FOXO4 have been associated with round cell sarcomas. Check the datasheet of any product for its validated reactivity.
Binding partners and fusion partners of CIC, including ATXN1 and ATXN1L, with research products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96RK0; product specifications from Assay Genie datasheets.