SYNE1
SYNE1 (spectrin repeat containing nuclear envelope protein 1), also known as Nesprin-1, enaptin, Nesp1 and CPG2, is a large modular protein of the nesprin family. It forms a linking network between organelles and the actin cytoskeleton and is a component of the LINC complex. Browse Assay Genie's current range of SYNE1 research reagents below, or read on for the biology behind the target.
SYNE1 is a multi-isomeric, modular protein that forms a linking network between organelles and the actin cytoskeleton, helping to maintain subcellular spatial organisation. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, it contributes to the connection between the nuclear lamina and the cytoskeleton. These nucleocytoplasmic interactions play an important role in transmitting mechanical forces across the nuclear envelope and in nuclear movement and positioning.
The SYNE1 protein may be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors, through LINC complex association with SUN1/2 and probably with cytoplasmic dynein-dynactin motor complexes. SYNE1 and SYNE2 may act redundantly in this role. It is also required for centrosome migration to the apical cell surface during early ciliogenesis, and may contribute to nuclear remodelling during sperm head formation, where a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.
The SYNE1 gene encodes a spectrin repeat containing protein that localises to the nuclear membrane and is expressed in skeletal and smooth muscle and in peripheral blood lymphocytes. Its subcellular locations include the nuclear outer membrane, the cytoskeleton, the sarcomere and the Golgi apparatus. Alternatively spliced transcript variants encode different isoforms. Mutations in SYNE1 have been associated with autosomal recessive spinocerebellar ataxia 8, also called autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce. HGNC lists it in the KASH domain containing group, and the mouse ortholog is Syne1.
SYNE1 is a LINC complex component linking the nuclear lamina to the cytoskeleton, making it central to studies of nucleocytoplasmic connection.
The LINC complex transmits mechanical forces across the nuclear envelope, and SYNE1 is relevant to work on nuclear movement and positioning.
SYNE1 may support nuclear migration in neural progenitors and is required for centrosome migration during early ciliogenesis.
SYNE1 mutations are associated with autosomal recessive spinocerebellar ataxia 8, and the protein is expressed in skeletal and smooth muscle.
SYNE1 is a component of the LINC complex, which connects the nuclear lamina to the cytoskeleton. It helps transmit mechanical forces across the nuclear envelope and contributes to nuclear movement and positioning, and it may also support nuclear migration in neural progenitors.
SYNE1 is also called Nesprin-1, enaptin, Nesp1, SYNE-1B, MYNE1, CPG2, SCAR8, ARCA1 and KIAA0796. A previous name was chromosome 6 open reading frame 98 (C6orf98). The gene produces multiple isoforms through alternative splicing.
Mutations in SYNE1 are associated with autosomal recessive spinocerebellar ataxia 8, also known as recessive ataxia of Beauce. The mouse ortholog is Syne1. Check the datasheet of any product for its validated reactivity.
Other nesprin family members and nuclear envelope LINC complex proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8NF91; product specifications from Assay Genie datasheets.