PTGES3
PTGES3 (prostaglandin E synthase 3, also known as p23, TEBP and cPGES) is a cytosolic enzyme that converts prostaglandin endoperoxide H2 to prostaglandin E2. It also acts as a molecular co-chaperone of HSP90, disrupting hormone-dependent transcriptional activation complexes on DNA. Browse Assay Genie's current range of PTGES3 research reagents below, or read on for the biology behind the target.
PTGES3 is a cytosolic prostaglandin synthase. It catalyses the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2), placing it in the prostaglandin biosynthetic pathway. The same protein has a second, separate role as a molecular chaperone. It localises to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation by promoting the disassembly of transcriptional regulatory complexes.
The NCBI Gene summary describes PTGES3 as a co-chaperone with heat shock protein 90 (HSP90) that localises to response elements in DNA and disrupts transcriptional activation complexes. It also facilitates hydroxylation of HIF alpha proteins through its interaction with EGLN1/PHD2, which recruits EGLN1/PHD2 to the HSP90 pathway. This ties the protein to both steroid-hormone receptor signalling and oxygen-sensing biology. Researchers studying the PTGES3 protein therefore work across lipid mediator synthesis, chaperone function and transcriptional regulation.
The PTGES3 gene belongs to the HGNC gene group of prostaglandin E synthases, and the protein belongs to the p23/wos2 family. Alternative splicing produces multiple transcript variants, and the genome contains multiple pseudogenes on several different chromosomes, which is worth bearing in mind when designing nucleic-acid assays. Aliases include p23, TEBP and cPGES, and the previous HGNC name was prostaglandin E synthase 3 (cytosolic). Mouse and rat both carry a Ptges3 ortholog.
PTGES3 converts PGH2 to PGE2 in the cytosol, making it relevant to studies of prostaglandin production.
As an HSP90 co-chaperone, PTGES3 is studied in chaperone-dependent assembly and disassembly of regulatory protein complexes.
PTGES3 localises to response elements and disrupts receptor-mediated transcriptional activation, supporting work on hormone-dependent gene regulation.
PTGES3 interacts with EGLN1/PHD2 to facilitate HIF alpha hydroxylation and recruits it to the HSP90 pathway.
PTGES3 has two documented roles. As a cytosolic enzyme it catalyses the oxidoreduction of PGH2 to PGE2. As a molecular co-chaperone of HSP90 it localises to response elements and promotes disassembly of transcriptional regulatory complexes, disrupting receptor-mediated transcriptional activation.
PTGES3 is also called p23, TEBP and cPGES, and its earlier HGNC name was prostaglandin E synthase 3 (cytosolic). The names reflect its dual identity as a prostaglandin synthase and as a p23-family chaperone. Alternative splicing gives multiple transcript variants.
Yes. Mouse and rat each have an ortholog named Ptges3. The human protein belongs to the p23/wos2 family. Cross-species use of any reagent depends on its reactivity, so check the datasheet of any product for its validated reactivity.
Other prostaglandin E synthases and related pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15185; product specifications from Assay Genie datasheets.