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Anti-P23/PTGES3 Antibody (CAB5194)

SKU:
CAB5194
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
P23
TEBP
cPGES
Research Area:
Metabolism
€139 - €419
Frequently bought together:

Description

Product Name:P23/PTGES3 Rabbit mAb
Product Code:CAB5194
Size:20uL, 50uL, 100uL
Synonyms:P23, TEBP, cPGES
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human P23/PTGES3
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Rat testis, Rat brain, HeLa, HepG2, Jurkat, Mouse testis, Mouse brain
Immunogen:A synthesized peptide derived from human P23/PTGES3
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10728
Uniprot:Q15185
Cellular Location:Cytoplasm
Calculated MW:23kDa
Observed MW:23kDa
UniProt Protein Function:TEBP: Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Belongs to the p23/wos2 family.
UniProt Protein Details:

Protein type:Transferase; Chaperone; Nuclear receptor co-regulator; EC 5.3.99.3; Isomerase

Chromosomal Location of Human Ortholog: 12q13.3|12

Cellular Component: chromosome, telomeric region; cytoplasm; cytosol; nucleoplasm; nucleus; telomerase holoenzyme complex

Molecular Function:prostaglandin-E synthase activity; protein binding; telomerase activity; unfolded protein binding

Biological Process: arachidonic acid metabolic process; cyclooxygenase pathway; prostaglandin biosynthetic process; RNA-dependent DNA replication; signal transduction; telomere maintenance

NCBI Summary:This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]
UniProt Code:Q15185
NCBI GenInfo Identifier:8928247
NCBI Gene ID:10728
NCBI Accession:Q15185.1
UniProt Secondary Accession:Q15185,Q8WU70, A8K7D0, B4DHP2, B4DP11, B4DP21,
UniProt Related Accession:Q15185
Molecular Weight:16,476 Da
NCBI Full Name:Prostaglandin E synthase 3
NCBI Synonym Full Names:prostaglandin E synthase 3
NCBI Official Symbol:PTGES3  
NCBI Official Synonym Symbols:P23; TEBP; cPGES  
NCBI Protein Information:prostaglandin E synthase 3
UniProt Protein Name:Prostaglandin E synthase 3
UniProt Synonym Protein Names:Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23
UniProt Gene Name:PTGES3  
UniProt Entry Name:TEBP_HUMAN

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