LMNB2
LMNB2 (lamin B2, also known as LMN2) is a B-type nuclear lamin and an intermediate filament protein. It forms part of the nuclear lamina, the fibrous meshwork on the nucleoplasmic side of the inner nuclear membrane. Browse Assay Genie's current range of LMNB2 research reagents below, or read on for the biology behind the target.
LMNB2 is an intermediate filament protein that assembles into a filamentous meshwork. Together with other lamins, it is a major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. The lamina provides a framework for the nuclear envelope and bridges the envelope and chromatin, so lamins contribute to nuclear assembly, chromatin organisation, and nuclear membrane and telomere dynamics.
The structural integrity of the lamina is strictly controlled by the cell cycle. The nuclear envelope disintegrates in prophase and re-forms in telophase. During mitosis the lamina matrix is reversibly disassembled as lamin proteins are phosphorylated. Lamins are thought to be involved in nuclear stability, chromatin structure and gene expression.
The LMNB2 gene encodes a B-type lamin. Vertebrate lamins fall into two types, A and B, and the family is highly conserved in evolution. The LMNB2 protein belongs to the intermediate filament family, and the mouse ortholog is Lmnb2. HGNC places the gene in the lamins group and also lists it among the microRNA protein coding host genes. Mutations in this gene are associated with acquired partial lipodystrophy. The previous symbol LMN2 may still appear in older literature.
LMNB2 helps form the lamina that frames the nuclear envelope, making it a core target for studying nuclear architecture and assembly.
Lamins bridge the nuclear envelope and chromatin, so LMNB2 is relevant to work on chromatin organisation and gene expression.
Lamina disassembly and re-formation are cell-cycle controlled and involve lamin phosphorylation, which makes LMNB2 useful for studying mitotic nuclear envelope dynamics.
Mutations in the LMNB2 gene are associated with acquired partial lipodystrophy, linking this lamin to disease-focused studies.
LMNB2 is a B-type lamin that assembles into the nuclear lamina beneath the inner nuclear membrane. It provides a framework for the nuclear envelope and links it to chromatin, contributing to nuclear assembly, chromatin organisation, and nuclear membrane and telomere dynamics.
LMNB2 is the HGNC symbol for lamin B2, and the UniProt entry is named Lamin-B2. LMN2 is an alias and previous symbol. The gene is classed with the lamins and with the microRNA protein coding host genes.
Lamins are highly conserved in evolution, and the mouse has an Lmnb2 ortholog. Mutations in the human LMNB2 gene are associated with acquired partial lipodystrophy. Check the datasheet of any product for its validated reactivity.
Other B-type lamins and nuclear lamina proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q03252; product specifications from Assay Genie datasheets.