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GNL3L
GNL3L (G protein nucleolar 3 like, also known as GNL3B or FLJ10613) is a nucleolar GTPase required for ribosomal pre-rRNA processing and cell proliferation. It also stabilises the telomere-binding protein TERF1 and the E3 ligase MDM2 by limiting their ubiquitination. Browse Assay Genie's current range of GNL3L research reagents below, or read on for the biology behind the target.
GNL3L binds GTP and belongs to the TRAFAC class YlqF/YawG GTPase family. It is required for normal processing of ribosomal pre-rRNA, and NCBI describes it as a nucleolar GTPase that is essential for pre-rRNA processing and for cell proliferation. The protein localises to the nucleolus within the nucleus.
Beyond ribosome biogenesis, GNL3L acts as a stabilising factor for several regulatory proteins. It stabilises TERF1 (TRF1) telomeric association by preventing TERF1 recruitment by PML. It also protects TERF1 from ubiquitination and proteasomal degradation by interfering with TERF1 binding to the FBXO4 E3 ubiquitin-protein ligase. By stabilising TRF1 protein during mitosis, GNL3L promotes the metaphase-to-anaphase transition.
GNL3L also stabilises MDM2 protein by preventing its ubiquitination and proteasomal degradation. Through its action on MDM2, it may affect TP53 activity. The GNL3L gene is located on the X chromosome, and the mouse ortholog is Gnl3l. Two transcript variants encoding the same protein have been reported. The gene was previously named guanine nucleotide binding protein-like 3 (nucleolar)-like, and the symbol GNL3B is a previous symbol for the same locus.
GNL3L is required for normal processing of ribosomal pre-rRNA, making it a useful target for studying nucleolar GTPases in ribosome assembly.
GNL3L stabilises TERF1 telomeric association and protects TERF1 from FBXO4-mediated degradation, linking it to telomere-binding protein regulation.
GNL3L is required for cell proliferation and promotes the metaphase-to-anaphase transition by stabilising TRF1 protein during mitosis.
By preventing MDM2 ubiquitination and degradation, GNL3L may affect TP53 activity, making it relevant to studies of protein turnover.
GNL3L is a nucleolar GTPase that binds GTP and is required for ribosomal pre-rRNA processing and cell proliferation. It also stabilises TERF1 and MDM2 by preventing their ubiquitination and proteasomal degradation, and by acting on MDM2 it may affect TP53 activity.
The HGNC name is G protein nucleolar 3 like, and UniProt lists guanine nucleotide-binding protein-like 3-like protein. Aliases include GNL3B and FLJ10613. An earlier name was guanine nucleotide binding protein-like 3 (nucleolar)-like. Two transcript variants encode the same protein.
A mouse ortholog, Gnl3l, is recorded for the human gene. GNL3L belongs to the TRAFAC class YlqF/YawG GTPase family. Check the datasheet of any product for its validated reactivity.
Other nucleolar GTPases, telomere-binding proteins, ubiquitin pathway components and p53 pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NVN8; product specifications from Assay Genie datasheets.
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