FMN1
FMN1 (formin 1) is a member of the formin homology family that contributes to the formation of adherens junctions and the polymerisation of linear actin cables. It is also known as FMN, LD or formin (limb deformity), reflecting its link to the mouse limb deformity phenotype. Browse Assay Genie's current range of FMN1 research reagents below, or read on for the biology behind the target.
FMN1 is a formin, a class of protein associated with the organisation of the actin cytoskeleton. The annotated function of the FMN1 protein is to play a role in the formation of adherens junctions and in the polymerisation of linear actin cables. Adherens junctions are cell-cell contacts, and linear actin cables are unbranched filament bundles, so FMN1 links actin assembly to how cells attach to one another.
Formin-1 belongs to the formin homology family and, within it, to the Cappuccino subfamily. HGNC places the FMN1 gene in the Formins gene group. UniProt records the protein in several compartments: the nucleus, the cytoplasm, adherens junctions at cell-cell contacts, and the cell membrane. Researchers studying the FMN1 gene may also encounter it under older identifiers, including DKFZP686C2281, FLJ45135, MGC125288 and MGC125289. NCBI Gene reports that alternatively spliced transcript variants have been found, so transcript-level context matters when designing experiments.
The name reflects the gene's history. The previous HGNC name, formin (limb deformity), refers to the fact that the homologous mouse gene, Fmn1, is associated with limb deformity. That link makes mouse Fmn1 a reference point for work on limb development and on cytoskeletal regulation. FMN2 is another formin that is often studied alongside FMN1 when comparing how family members contribute to actin organisation.
FMN1 supports the polymerisation of linear actin cables, making it a relevant formin for studying how unbranched actin structures are built.
FMN1 contributes to the formation of adherens junctions, so it is studied in work on cell-cell adhesion and junction assembly.
The homologous mouse gene is associated with limb deformity, which ties FMN1 research to developmental genetics.
As a Cappuccino subfamily formin, FMN1 is used in comparative studies of formin homology proteins and their roles in actin dynamics.
FMN1 plays a role in the formation of adherens junctions and in the polymerisation of linear actin cables. It is a formin homology family protein, so its activity centres on organising the actin cytoskeleton at sites of cell-cell contact. UniProt records it in the nucleus, cytoplasm, adherens junctions and cell membrane.
FMN1 is also called FMN and LD, with former symbols DKFZP686C2281, FLJ45135, MGC125288 and MGC125289. Its earlier name was formin (limb deformity). NCBI Gene reports alternatively spliced transcript variants, so check which variant a reagent targets before use.
Mouse has an ortholog, Fmn1, and the homologous mouse gene is associated with limb deformity, which gave the gene its earlier name. The sources supplied do not describe a specific human disease link. Check the datasheet of any product for its validated reactivity.
Other formin family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q68DA7; product specifications from Assay Genie datasheets.