DCLK1
DCLK1 (doublecortin like kinase 1, also known as DCAMKL1, DCLK, DCDC3A and KIAA0369) is a probable serine/threonine kinase of the doublecortin family. It has been linked to calcium-signalling control of neuronal migration in the developing brain. Browse Assay Genie's current range of DCLK1 research reagents below, or read on for the biology behind the target.
DCLK1 is a probable kinase that may be involved in a calcium-signalling pathway controlling neuronal migration in the developing brain, and it may also participate in functions of the mature nervous system. It is involved in several cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. The DCLK1 protein belongs to the protein kinase superfamily, in the CAMK Ser/Thr protein kinase family and the CaMK subfamily.
The protein has a modular structure. Two N-terminal doublecortin domains bind microtubules and regulate microtubule polymerisation. A C-terminal serine/threonine protein kinase domain shows substantial homology to Ca2+/calmodulin-dependent protein kinase. Between them lies a serine/proline-rich domain that mediates multiple protein-protein interactions. The microtubule-polymerising activity of DCLK1 is independent of its kinase activity. The DCLK1 gene is up-regulated by brain-derived neurotrophic factor and has been associated with memory and general cognitive abilities. Mouse and rat both carry a Dclk1 ortholog.
Multiple transcript variants arise from two alternative promoters and alternative splicing, although the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms that are differentially expressed and have different kinase activities. HGNC classes the gene in the doublecortin superfamily and the doublecortin like kinase family. Previous names include doublecortin and CaM kinase-like 1 and doublecortin-like kinase 1, which explains the DCAMKL1 alias still found in the literature.
DCLK1 may act in a calcium-signalling pathway controlling neuronal migration in the developing brain.
Its doublecortin domains bind microtubules and regulate polymerisation, independently of kinase activity.
DCLK1 is involved in neurogenesis, retrograde transport and neuronal apoptosis.
The gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities.
DCLK1 is a probable serine/threonine kinase that may be involved in a calcium-signalling pathway controlling neuronal migration in the developing brain. It may also participate in mature nervous system functions. Its doublecortin domains bind microtubules and regulate their polymerisation, independently of kinase activity.
DCLK1 is also called DCAMKL1, DCLK, DCDC3A and KIAA0369; earlier names were doublecortin and CaM kinase-like 1 and doublecortin-like kinase 1. Two alternative promoters and alternative splicing produce transcript variants encoding isoforms that are differentially expressed and have different kinase activities.
Mouse and rat both have a Dclk1 ortholog. DCLK1 belongs to the doublecortin like kinase family, which also includes DCLK2, and to the CAMK Ser/Thr protein kinase family. Check the datasheet of any product for its validated reactivity.
Other doublecortin like kinase family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15075; product specifications from Assay Genie datasheets.