C2CD6

C2CD6

Target · Sperm ion channel subunit

C2CD6 Cation channel sperm-associated targeting subunit tau · CATSPERT

C2CD6 (C2 calcium dependent domain containing 6), also known as CATSPERT, ALS2CR11 and FLJ25351, is an auxiliary component of the CatSper complex. It supports sperm hyperactivation by targeting CatSper channel complexes to the elongating sperm flagellum. Browse Assay Genie's current range of C2CD6 research reagents below, or read on for the biology behind the target.

Flagellum membrane proteinCatSper auxiliary subunitContains a C2 domain
1820 aa
Protein length
~209 kDa
Molecular weight
2q33.1
Gene locus
C2 domain
Protein family
Target information

What is C2CD6 (catsper channel auxiliary subunit tau)?

C2CD6 is an auxiliary component of the CatSper complex, a channel complex involved in sperm cell hyperactivation. Hyperactivation is needed for sperm motility, which is essential late in the preparation of sperm for fertilisation. Within this system C2CD6 has a targeting role: it is required for CatSper complex targeting and trafficking into the quadrilinear nanodomains of the flagellum.

According to UniProt, C2CD6 targets preassembled CatSper complexes to elongating flagella, where it links the channel-carrying vesicles and motor proteins. The protein is annotated as localised to the flagellum membrane, a cell projection of the sperm cell. The C2CD6 protein contains a calcium-dependent membrane targeting C2 domain, a domain often found in proteins involved in membrane trafficking and signal transduction. HGNC places the gene in the C2 domain containing group and the CatSpermasome complex group.

The official gene symbol is CATSPERT (catsper channel auxiliary subunit tau), and the C2CD6 gene has also been listed as ALS2CR11 and FLJ25351. Earlier names, such as amyotrophic lateral sclerosis 2 chromosome region candidate 11, reflect the fact that an autosomal recessive form of juvenile amyotrophic lateral sclerosis was originally mapped to a region of chromosome 2 that includes this gene. The mouse ortholog is called Catspert.

Sperm motility research

C2CD6 is an auxiliary CatSper component involved in sperm hyperactivation, which is needed for sperm motility late in preparation for fertilisation.

Ion channel trafficking

C2CD6 targets preassembled CatSper complexes to elongating flagella, linking channel-carrying vesicles with motor proteins.

Flagellar membrane organisation

The protein is required for CatSper targeting into quadrilinear nanodomains, making it relevant to studies of flagellar membrane compartments.

C2 domain biology

C2CD6 carries a calcium-dependent membrane targeting C2 domain, a feature of proteins involved in membrane trafficking and signal transduction.

Background

C2CD6 frequently asked questions

What does C2CD6 do?

C2CD6 is an auxiliary component of the CatSper complex, which is involved in sperm cell hyperactivation. It is required for CatSper complex targeting and trafficking into quadrilinear nanodomains, and it targets preassembled complexes to elongating flagella, linking channel-carrying vesicles and motor proteins.

What other names does C2CD6 have?

The HGNC symbol is CATSPERT, for catsper channel auxiliary subunit tau. Other names are ALS2CR11 and FLJ25351, and the earlier name C2 calcium dependent domain containing 6. UniProt calls it cation channel sperm-associated targeting subunit tau.

Is C2CD6 linked to amyotrophic lateral sclerosis?

Only through history. An autosomal recessive form of juvenile amyotrophic lateral sclerosis was originally mapped to a chromosome 2 region that includes this gene, which gave rise to the ALS2CR11 name. The data supplied describe its function in the sperm CatSper complex. A mouse ortholog, Catspert, exists.

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Related targets

Other CatSper complex subunits and sperm ion channel components with products at Assay Genie.

Gene and protein annotations from HGNC, NCBI Gene and UniProt Q53TS8; product specifications from Assay Genie datasheets.

C2CD6 Product listing

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