FSIP1
FSIP1 (fibrous sheath interacting protein 1, also known as FLJ35989) is a human protein and the founding member of the FSIP1 family. It is predicted to contribute to axoneme assembly, vesicle organisation and tissue cell-number homeostasis, with predicted activity in the sperm head. Browse Assay Genie's current range of FSIP1 research reagents below, or read on for the biology behind the target.
FSIP1 is a protein whose function is currently described mainly through prediction rather than detailed biochemical characterisation. According to the NCBI Gene summary, it is predicted to act upstream of or within several processes, including axoneme assembly, homeostasis of the number of cells within a tissue, and vesicle organisation. The axoneme is the microtubule-based core of the sperm flagellum, so these annotations point towards a role in sperm structure and development, although no UniProt function annotation is available to confirm a specific mechanism.
The same summary predicts that FSIP1 is active in the acrosomal vesicle, the nucleus and the sperm head. UniProt does not currently annotate a subcellular location for the protein. UniProt classifies the protein as belonging to the FSIP1 family. The human FSIP1 gene is found at 15q14 and encodes a protein of 581 amino acids; the facts card lists the identifiers for HGNC, NCBI Gene and UniProt. Orthologues are recorded in mouse and rat, both named Fsip1, which allows comparative work in rodent models.
The name reflects the protein's description as a fibrous sheath interacting protein, and FLJ35989 is a recorded alias. Because the available annotation is predicted rather than experimentally detailed, researchers studying FSIP1 should treat the process and location assignments above as working hypotheses. Studies of FSIP1 expression and localisation are therefore a natural way to test them.
FSIP1 is predicted to be active in the sperm head and acrosomal vesicle, making it a candidate for studies of sperm structure.
The gene is predicted to act upstream of or within axoneme assembly, a process central to flagellar formation.
Predicted involvement in vesicle organisation links FSIP1 to studies of the acrosomal vesicle and related trafficking.
FSIP1 is predicted to act in homeostasis of cell number within a tissue, an area open to further investigation.
The function of FSIP1 is not yet fully defined. The NCBI Gene summary predicts that it acts upstream of or within axoneme assembly, vesicle organisation and tissue cell-number homeostasis, and that it is active in the acrosomal vesicle, nucleus and sperm head.
The HGNC full name is fibrous sheath interacting protein 1, and UniProt lists it as fibrous sheath-interacting protein 1. FLJ35989 is a recorded alias. No previous HGNC names are listed, and the protein belongs to the FSIP1 family.
Yes, orthologues exist in mouse and rat, and both are named Fsip1. This allows the gene to be studied in rodent models. Check the datasheet of any product for its validated reactivity.
Other sperm-associated proteins and flagellar structure targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8NA03; product specifications from Assay Genie datasheets.