S100P
S100P (S100 calcium binding protein P) is a small EF-hand calcium-binding protein of the S100 family. It may act as a calcium sensor, interacting with partner proteins in a calcium-dependent manner and contributing to cellular calcium signalling. Browse Assay Genie's current range of S100P research reagents below, or read on for the biology behind the target.
S100P may function as a calcium sensor and contribute to cellular calcium signalling. In a calcium-dependent manner it works by interacting with other proteins, including EZR (ezrin) and PPP5C, and indirectly plays a role in physiological processes such as the formation of microvilli in epithelial cells. It may also stimulate cell proliferation in an autocrine manner through activation of the receptor for activated glycation end products (RAGE).
The S100P protein belongs to the S100 family, whose members contain two EF-hand calcium-binding motifs. S100 proteins are found in the cytoplasm and/or nucleus of a wide range of cells and are involved in regulating cellular processes such as cell cycle progression and differentiation. In addition to binding Ca2+, S100P also binds Zn2+ and Mg2+. UniProt lists its subcellular locations as the nucleus, the cytoplasm and the microvillus membrane of cell projections.
Most S100 genes sit together as a cluster on chromosome 1q21, but the S100P gene lies at 4p16, outside that cluster. HGNC places it in the S100 calcium binding proteins and EF-hand domain containing gene groups, and its previous name was S100 calcium-binding protein P. According to the NCBI Gene summary, the protein may play a role in the aetiology of prostate cancer.
S100P is proposed to act as a calcium sensor, making it a useful subject for studying calcium-dependent protein interactions.
Through calcium-dependent interaction with EZR, S100P indirectly contributes to microvilli formation in epithelial cells.
S100P may stimulate autocrine cell proliferation by activating RAGE, linking it to growth-signalling studies.
The NCBI Gene summary notes that S100P may play a role in the aetiology of prostate cancer.
S100P may function as a calcium sensor and contribute to calcium signalling. It interacts with proteins such as EZR and PPP5C in a calcium-dependent manner, indirectly supports microvilli formation in epithelial cells, and may stimulate autocrine cell proliferation through RAGE.
The HGNC name is S100 calcium binding protein P, and UniProt names the protein Protein S100-P. No other aliases are recorded. It belongs to the S100 family of EF-hand calcium-binding proteins, which bind Ca2+ and, in the case of S100P, also Zn2+ and Mg2+.
The NCBI Gene summary states that S100P may play a role in the aetiology of prostate cancer. Unlike many S100 genes, which cluster on chromosome 1q21, the S100P gene is located at 4p16. Check the datasheet of any product for its validated reactivity.
Other S100 family proteins, S100P interaction partners and the RAGE receptor, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P25815; product specifications from Assay Genie datasheets.