RPS6KA6
RPS6KA6, also known as RSK4 and ribosomal protein S6 kinase alpha-6, is a constitutively active serine/threonine-protein kinase of the ribosomal S6 kinase family. Unlike related kinases, it shows growth-factor-independent activity. Browse Assay Genie's current range of RPS6KA6 research reagents below, or read on for the biology behind the target.
RPS6KA6 is a serine/threonine-protein kinase that is constitutively active and exhibits growth-factor-independent kinase activity. UniProt annotation indicates that it may participate in p53/TP53-dependent cell growth arrest signalling and may play an inhibitory role during embryogenesis. As a kinase, it catalyses the transfer of phosphate to serine or threonine residues on substrate proteins (EC 2.7.11.1), and it is found in the cytosol and the nucleus.
The RPS6KA6 gene encodes a member of the ribosomal S6 kinase family, whose members are generally regulated by growth factors. The NCBI Gene summary notes that RPS6KA6 may be distinct from other family members: studies suggest it is not growth factor dependent and may not participate in the same signalling pathways. The protein belongs to the protein kinase superfamily, the AGC Ser/Thr protein kinase family and the S6 kinase subfamily. HGNC classifies it within the MAPK activated protein kinases and the ribosomal protein S6 kinase family. A mouse ortholog, Rps6ka6, is recorded.
The symbol RPS6KA6 and the alias RSK4 are both in common use, and the previous HGNC name was ribosomal protein S6 kinase, 90kD, polypeptide 6. Researchers working with the RPS6KA6 gene or RSK4 protein often compare it with other RSK family kinases such as RPS6KA1, RPS6KA2 and RPS6KA3 to separate its distinctive regulation from the growth-factor-dependent members.
RPS6KA6 may participate in p53/TP53-dependent cell growth arrest signalling, making it a candidate for studies of how cell growth is restrained.
UniProt annotation suggests RPS6KA6 may play an inhibitory role during embryogenesis, relevant to developmental signalling research.
As a constitutively active AGC-family kinase, RPS6KA6 offers a contrast with growth-factor-regulated S6 kinases in signalling studies.
RPS6KA6 appears to differ from other ribosomal S6 kinases in regulation and pathway involvement, supporting comparative analyses across the family.
RPS6KA6 is a constitutively active serine/threonine-protein kinase with growth-factor-independent activity. It may participate in p53/TP53-dependent cell growth arrest signalling and may play an inhibitory role during embryogenesis. It is found in the cytosol and nucleus.
RPS6KA6 is also called RSK4. UniProt names it ribosomal protein S6 kinase alpha-6, HGNC lists ribosomal protein S6 kinase A6, and a previous name was ribosomal protein S6 kinase, 90kD, polypeptide 6.
RPS6KA6 belongs to the AGC Ser/Thr protein kinase family, S6 kinase subfamily, but appears distinct because it is not growth factor dependent. A mouse ortholog, Rps6ka6, exists; check the datasheet of any product for its validated reactivity.
Other ribosomal S6 kinases, MAPK-activated protein kinases and ribosomal protein targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UK32; product specifications from Assay Genie datasheets.