KLF15
KLF15 (KLF transcription factor 15, also known as KKLF) is a nuclear C2H2-type zinc-finger transcriptional regulator of the Krueppel-like factor family. It controls gene expression in the heart and kidney, including programmes linked to cardiac fibrosis, hypertrophy and podocyte differentiation. Browse Assay Genie's current range of KLF15 research reagents below, or read on for the biology behind the target.
KLF15 is a transcriptional regulator that binds DNA at specific promoter elements. It binds the GA element of the CLCNKA promoter and the KCNIP2 promoter, where it regulates circadian expression of KCNIP2 in the heart. NCBI Gene annotation describes it as enabling RNA polymerase II-specific, sequence-specific DNA binding at cis-regulatory regions, with a role in positively regulating transcription by RNA polymerase II. The protein is located in nuclear speckles.
A large part of the literature on KLF15 concerns cardiac biology. It acts as a repressor of CCN2 expression and is involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy, acting through inhibition of MEF2A and GATA4, and it inhibits MYOCD activity. Beyond the heart, KLF15 is involved in podocyte differentiation.
KLF15 also influences acetylation-dependent signalling. It is a negative regulator of TP53 acetylation, and it inhibits NF-kappa-B activation by repressing EP300-dependent acetylation of RELA, in line with its annotated role in negative regulation of peptidyl-lysine acetylation. The KLF15 protein belongs to the Sp1 C2H2-type zinc-finger family and sits in the HGNC group of KLF transcription factors. The KLF15 gene was previously named Kruppel like factor 15 and carries the alias KKLF; the mouse ortholog is Klf15.
KLF15 represses CCN2 expression and is involved in controlling cardiac fibrosis, making it a focus for studies of fibrotic gene regulation.
KLF15 acts through inhibition of MEF2A and GATA4 and inhibits MYOCD activity, linking it to transcriptional control of hypertrophy.
KLF15 binds the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart.
KLF15 is involved in podocyte differentiation and binds the GA element of the CLCNKA promoter.
KLF15 is a nuclear transcription factor. It binds promoters such as CLCNKA and KCNIP2, represses CCN2 to help control cardiac fibrosis, inhibits MEF2A and GATA4 in cardiac hypertrophy, and is involved in podocyte differentiation. It also limits TP53 and RELA acetylation.
The HGNC name is KLF transcription factor 15, the UniProt name is Krueppel-like factor 15, and the alias is KKLF. The previous name was Kruppel like factor 15. All refer to the same gene, KLF15, located on chromosome 3.
KLF15 has a mouse ortholog, Klf15, so it can be studied in mouse models. The protein belongs to the Sp1 C2H2-type zinc-finger family and the KLF transcription factor group. Check the datasheet of any product for its validated reactivity.
Other Krueppel-like factor transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UIH9; product specifications from Assay Genie datasheets.