CD109
CD109 (CD109 molecule, also known as CD109 antigen, HPA-15 and CPAMD7) is a GPI-linked cell surface glycoprotein that negatively regulates transforming growth factor beta signalling. It belongs to the alpha-2-macroglobulin family and is found on platelets, activated T-cells and endothelial cells. Browse Assay Genie's current range of CD109 research reagents below, or read on for the biology behind the target.
CD109 is a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that sits at the cell surface. Its best-described function is as a negative modulator of signalling by transforming growth factor beta (TGF-beta): the protein binds TGF-beta and dampens signalling, and UniProt specifically annotates this activity in keratinocytes, where it modulates TGFB1 signalling negatively. This makes CD109 a useful target for researchers studying how TGF-beta responses are restrained at the cell membrane.
According to NCBI Gene, the CD109 gene encodes a protein that localises to the surface of platelets, activated T-cells and endothelial cells. The protein is classed in the protease inhibitor I39 (alpha-2-macroglobulin) family, and HGNC places it in the C3 and PZP like, alpha-2-macroglobulin domain containing gene group. Multiple transcript variants encoding different isoforms have been reported for the gene, so researchers working with CD109 protein should consider which isoform is relevant to their system. The mouse ortholog is Cd109.
CD109 appears in HGNC under the group of CD molecules and also under human platelet antigens. Its previous name, CD109 antigen (Gov platelet alloantigens), reflects this platelet-antigen history, and HPA-15 remains a common alias. Other aliases include CPAMD7, FLJ38569 and DKFZp762L1111. Studies of the CD109 gene and its product therefore span platelet biology, T-cell activation, endothelial cells and TGF-beta signalling.
CD109 binds TGF-beta and negatively regulates its signalling, making it a point of interest for studying how this pathway is controlled.
UniProt annotates CD109 as a negative modulator of TGFB1 signalling in keratinocytes, relevant to work on skin cell responses.
CD109 carries the Gov platelet alloantigens (HPA-15) and is expressed on the platelet surface, linking it to platelet antigen research.
The glycoprotein localises to activated T-cells and endothelial cells, supporting investigation of its role on these cell surfaces.
CD109 is a GPI-linked cell surface glycoprotein that binds transforming growth factor beta (TGF-beta) and negatively regulates its signalling. UniProt notes that it negatively modulates TGFB1 signalling in keratinocytes. It localises to platelets, activated T-cells and endothelial cells.
CD109 is also known as CD109 antigen, HPA-15, CPAMD7, FLJ38569 and DKFZp762L1111. Its earlier name was CD109 antigen (Gov platelet alloantigens). NCBI Gene reports multiple transcript variants that encode different isoforms, so check which isoform an experiment addresses.
A mouse ortholog, Cd109, is recorded for the human gene. CD109 belongs to the alpha-2-macroglobulin (I39) protease inhibitor family. Check the datasheet of any product for its validated reactivity before planning cross-species work.
Other CD molecules, endothelial and immune cell surface markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6YHK3; product specifications from Assay Genie datasheets.